INT284882

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn5a) plasma membrane (Scn5a) transmembrane transport (Scn5a)
Anatomy Link Frequency
ventricles 2
Scn5a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 44 99.98 Very High Very High Very High
Eae 6 87.40 High High
Action potential 64 82.00 Quite High
nav1.3 4 54.00 Quite High
anesthesia 2 46.88 Quite Low
addiction 14 5.00 Very Low Very Low Very Low
action potential duration 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Nav1.1 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 6 99.98 Very High Very High Very High
Fibrosis 38 94.68 High High
Anxiety Disorder 4 87.88 High High
Targeted Disruption 20 87.08 High High
Congenital Anomalies 6 85.44 High High
Body Weight 6 82.36 Quite High
Aging 20 80.84 Quite High
Stress 2 77.40 Quite High
Ventricular Tachycardia 44 60.48 Quite High
Heart Arrhythmia 50 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semi-quantitative assessment of cardiac fibrosis led to mean scores of 1.88±0.40 in Scn5a+/?
Positive_regulation (led) of Scn5a associated with fibrosis and cardiovascular disorder under development
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 1.12 Pain Relevance 0.30
Scn5a transcript levels were similar in both groups of Scn5a+/?
Positive_regulation (groups) of Scn5a
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.16 Pain Relevance 0.05
An increase in the Scn5a mRNA was observed only in the right ventricles of Scn3b?
Positive_regulation (increase) of Scn5a in ventricles
3) Confidence 0.44 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.17 Pain Relevance 0.04
These hearts also showed increased expression levels of Scn1b mRNA in both ventricles and Scn5a mRNA in the right ventricles compared to findings in WT hearts.
Positive_regulation (increased) of Scn5a in ventricles
4) Confidence 0.44 Published 2008 Journal Prog Biophys Mol Biol Section Abstract Doc Link PMC2764399 Disease Relevance 0.28 Pain Relevance 0.04

General Comments

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