INT284916

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.66
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IL1RN, HDAC4) cytoplasm (IL1RN, HDAC4) cytosol (HDAC4)
extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
Anatomy Link Frequency
HeLa 1
IL1RN (Homo sapiens)
HDAC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 6 51.12 Quite High
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 6 97.76 Very High Very High Very High
Anorexia 7 96.92 Very High Very High Very High
Bartter Syndrome 1 96.20 Very High Very High Very High
Vomiting 20 95.68 Very High Very High Very High
Diarrhoea 6 95.28 Very High Very High Very High
Cancer 47 94.68 High High
Colon Cancer 1 72.88 Quite High
Leukemia 18 71.20 Quite High
Toxicity 13 69.44 Quite High
Solid Tumor 8 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PXD101 (belinostat) is a novel hydroxamate-type inhibitor of histone deacetylase activity that inhibits histone deacetylase activity in HeLa cell extracts with an IC50 of 27 nM and induces a concentration-dependent increase in acetylation of histone H4 in tumor cell lines.
inhibitor Negative_regulation (inhibits) of histone deacetylase in HeLa associated with cancer
1) Confidence 0.00 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.66 Pain Relevance 0.03

General Comments

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