INT284918

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RUNX1T1, DNMT1) DNA binding (RUNX1T1, DNMT1) generation of precursor metabolites and energy (RUNX1T1)
transcription factor binding (DNMT1)
RUNX1T1 (Homo sapiens)
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 46 99.16 Very High Very High Very High
Genetic Translocation 1 97.64 Very High Very High Very High
Cancer 47 91.68 High High
Leukemia 18 79.40 Quite High
Myelodysplastic Syndromes 58 73.20 Quite High
Acute Promyelocytic Leukemia 1 59.76 Quite High
Repression 1 10.84 Low Low
Vomiting 20 5.00 Very Low Very Low Very Low
Toxicity 13 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PML/RAR, AML1/ETO), exert their oncogenic effect by an aberrant recruitment of repressor complexes, containing DNMT and HDAC activities, on genes that are relevant for hematopoietic differentiation [31].
ETO Regulation (effect) of DNMT
1) Confidence 0.21 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.09 Pain Relevance 0

General Comments

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