INT284919

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (XRCC6, BAX) nucleus (XRCC6, BAX) nucleoplasm (XRCC6)
mitochondrion (BAX) lyase activity (XRCC6) endoplasmic reticulum (BAX)
XRCC6 (Homo sapiens)
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 5.52 Low Low
Bioavailability 6 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 13 97.88 Very High Very High Very High
Death 4 79.68 Quite High
Cancer 47 69.64 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Myeloid Leukemia 46 13.44 Low Low
Vomiting 20 5.00 Very Low Very Low Very Low
Leukemia 18 5.00 Very Low Very Low Very Low
Toxicity 13 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Fatigue 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was demonstrated that the DNA damage associated protein, Ku70, in its deacetylated form (maintained by several HDACs), keeps BAX away from the mitochondrion and protects cells from apoptosis.
Ku70 Negative_regulation (keeps) of BAX associated with apoptosis
1) Confidence 0.01 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.64 Pain Relevance 0

General Comments

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