INT284938

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 29 99.84 Very High Very High Very High
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 33 99.84 Very High Very High Very High
Genomic Instability 2 98.52 Very High Very High Very High
Cancer 53 73.84 Quite High
Reproductive System Disorders 4 72.04 Quite High
Death 8 67.44 Quite High
Mixed Connective Tissue Disorder 2 51.52 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Choristoma 3 6.80 Low Low
Myeloid Leukemia 46 5.00 Very Low Very Low Very Low
Vomiting 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After integration into DNA of replicating cells, the 5-azacytosine ring covalently bind the mantainance methyltransferase DNMT1 that is then polyubiquitinated and targeted for degradation in the proteosome [58].
Regulation (targeted) of DNMT1
1) Confidence 0.22 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.25 Pain Relevance 0
It has been demonstrated that DNMT1, DNMT3A, and DNMT3B are disregulated in endometriosis [48], and it has been suggested that aberrant methylation of HOXA10 and of the progesterone receptor PR-B may be responsible of the disregulation of their expression in endometriosis.
Regulation (disregulated) of DNMT1 associated with endometriosis
2) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2837904 Disease Relevance 0.91 Pain Relevance 0.24

General Comments

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