INT284941

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN2B) nucleus (CDKN2B) kinase activity (CDKN2B)
cytoplasm (CDKN2B)
CDKN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 18 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 3 99.76 Very High Very High Very High
Death 12 96.56 Very High Very High Very High
Recurrence 9 95.96 Very High Very High Very High
Apoptosis 39 92.00 High High
Myelodysplastic Syndromes 174 91.36 High High
Cancer 141 83.52 Quite High
Myeloid Leukemia 138 80.32 Quite High
Acute Promyelocytic Leukemia 3 64.16 Quite High
Leukemia 54 54.84 Quite High
Fever 15 44.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly lower baseline methylation occurred in responders (9.8% versus 16.2% in non-responders), while hypermethylation over 24% and absent p15 mRNA expression were associated to lack of response.
Neg (absent) Transcription (expression) of p15
1) Confidence 0.63 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.19 Pain Relevance 0
Furthermore in acute myelogenous leukemia, increased p15 methylation levels were found in CD34+ cells of many leukemic patients in haematological remission and was associated with a high relapse rate and significantly reduced relapse-free survival [46].
Transcription (found) of p15 associated with acute myeloid leukemia and recurrence
2) Confidence 0.60 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.09 Pain Relevance 0
Although a modest but significant increment on p15 and p21 mRNA expression was detected, this was not associated with clinical response.
Transcription (expression) of p15
3) Confidence 0.47 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.31 Pain Relevance 0

General Comments

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