INT284952

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HAT1) nucleolus (HAT1) nucleus (HAT1)
transferase activity, transferring acyl groups (HAT1) cytoplasm (HAT1)
Anatomy Link Frequency
tails 1
HAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 98.08 Very High Very High Very High
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 58 50.00 Quite Low
Cancer 47 36.88 Quite Low
Leukemia 18 36.00 Quite Low
Myeloid Leukemia 46 5.00 Very Low Very Low Very Low
Vomiting 20 5.00 Very Low Very Low Very Low
Toxicity 13 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Fatigue 9 5.00 Very Low Very Low Very Low
Solid Tumor 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These enzymes cause chromatin modifications by affecting: i) the methylation status of cytosine in the DNA CpG dinucleotide (DNMTs); ii) the amino terminal tails of the core histones that protrude through the DNA and are exposed on the nucleosome surface, including, acetylation and deacetylation of lysines, methylation and demethylation of lysine and arginines (HAT, HDACs, HMTs, HTDs), phosphorylation of serines and threonines and others; iii) the adenosine triphosphate-dependent SWI/SNF complex [1-3].
Phosphorylation (phosphorylation) of HAT in tails associated with adenocard
1) Confidence 0.05 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0 Pain Relevance 0.05

General Comments

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