INT284955

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
internal 1
external 1
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 74 96.64 Very High Very High Very High
Osteoarthritis 36 96.36 Very High Very High Very High
Inflammation 25 86.44 High High
cytokine 5 72.08 Quite High
Inflammatory mediators 2 66.72 Quite High
Arthritis 5 42.20 Quite Low
corticosteroid 2 20.00 Low Low
Bioavailability 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 75 96.64 Very High Very High Very High
Frailty 38 96.36 Very High Very High Very High
INFLAMMATION 30 86.44 High High
Repression 2 80.40 Quite High
Disease 20 75.20 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Cancer 55 50.00 Quite Low
Necrosis 4 50.00 Quite Low
Arthritis 5 42.20 Quite Low
Injury 1 26.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because HDAC1 and HDAC2 are localized mainly at the cell nuclei, we compared the nuclear protein levels of HDACs between RA and OA, with lamin A as an internal control, and showed a significant increase of HDAC1 protein in RA cells.
Localization (localized) of HDAC1 in internal associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.63 Pain Relevance 0.74
The cellular sublocalization of HDAC class I is constitutively nuclear and dynamically affects gene regulation, while HDAC class II translocates from the cytoplasm to the nucleus in response to external stimuli.
Localization (sublocalization) of HDAC class I in external
2) Confidence 0.35 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.08 Pain Relevance 0

General Comments

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