INT284958

Context Info Confidence 0.25 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.56 Pain Relevance 0.04

cytosol (HDAC6) nucleolus (HDAC6) nucleus (HDAC6) intracellular (HDAC6) enzyme binding (HDAC6) cytoplasm (HDAC6)

Anatomy Link Frequency HeLa 1 HDAC6 (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 6 85.12 Potency 4 5.00 adenocard 1 5.00 anticonvulsant 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Cv General 2 Under Development 1 83.04 Anorexia 7 82.48 Cancer 47 82.16 Volume Depletion And Dehydration 2 82.08 Dysgeusia 1 81.56 Vomiting 20 81.12 Fatigue 9 80.40 Leukemia 18 79.60 Solid Tumor 8 78.60 Toxicity 13 75.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In HDAC enzyme activity assay, the benzamide analogs CI994, MS275 and MGCD0103 are partial inhibitors of HeLa nuclear extract HDACs activity, as they show full and potent inhibition of HDAC1 and 3 isoenzymes, but no inhibition of HDAC6 occurs and high ?

Negative_regulation (inhibition) of HDAC6 in HeLa

1) Confidence 0.25 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.56 Pain Relevance 0.04

General Comments

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