INT284961

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FLT3)
FLT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 6 67.96 Quite High
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 18 98.96 Very High Very High Very High
Shock 1 98.64 Very High Very High Very High
Cancer 47 85.84 High High
Apoptosis 13 84.92 Quite High
Lymphatic System Cancer 4 76.16 Quite High
Vomiting 20 50.40 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Diarrhoea 6 49.76 Quite Low
Bartter Syndrome 1 48.16 Quite Low
Anorexia 7 47.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They have been extensively studied for their ability to induce acetylation and to inhibit the ATP binding and chaperone function of heat shock protein (HSP) 90, promoting the polyubiquitylation and proteasomal degradation of the pro-growth and prosurvival client proteins Bcr-Abl, mutant FLT-3, c-Raf, and AKT in human leukemia cells [123].
Protein_catabolism (degradation) of mutant FLT-3 associated with leukemia and shock
1) Confidence 0.01 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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