INT284973

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.59
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
HeLa 2
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 6 87.76 High High
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 1 85.68 High High
Anorexia 7 85.12 High High
Volume Depletion And Dehydration 2 84.72 Quite High
Dysgeusia 1 84.20 Quite High
Vomiting 20 83.76 Quite High
Fatigue 9 83.04 Quite High
Solid Tumor 8 81.24 Quite High
Cancer 47 78.56 Quite High
Toxicity 13 78.32 Quite High
Colon Cancer 1 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In HDAC enzyme activity assay, the benzamide analogs CI994, MS275 and MGCD0103 are partial inhibitors of HeLa nuclear extract HDACs activity, as they show full and potent inhibition of HDAC1 and 3 isoenzymes, but no inhibition of HDAC6 occurs and high ?
Negative_regulation (show) of Negative_regulation (inhibition) of HDAC1 in HeLa
1) Confidence 0.20 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.59 Pain Relevance 0.04

General Comments

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