INT284979

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HIST2H4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 7 80.84 Quite High
Potency 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 28 99.62 Very High Very High Very High
Cancer 94 99.36 Very High Very High Very High
Apoptosis 18 98.90 Very High Very High Very High
Lymphatic System Cancer 19 89.04 High High
Ovarian Cancer 13 85.92 High High
Fatigue 27 84.60 Quite High
Vomiting 49 84.08 Quite High
Shock 1 82.40 Quite High
Multiple Myeloma 2 81.44 Quite High
Non-small-cell Lung Cancer 8 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As other HDACIs, at nanomolar concentrations they induce growth arrest and apoptosis of a variety of cancer and leukemia cell types, cause hyperacetylation of H3 and H4 histones, increase p21 levels, and induce cell cycle G1 phase accumulation [122].
H4 Binding (hyperacetylation) of associated with leukemia, cancer and apoptosis
1) Confidence 0.05 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.59 Pain Relevance 0.04
LBH589, a novel hydroxamate analog HDAC inhibitor, has been shown to induce acetylation of histone H3 and H4, increase p21 levels, disrupt the chaperone function of hsp90, and induce cell-cycle G1 phase accumulation and apoptosis of K562 cells and acute leukemia MV4-11 cells [102].
H4 Binding (acetylation) of associated with leukemia and apoptosis
2) Confidence 0.04 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.41 Pain Relevance 0

General Comments

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