INT284981

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 2 86.64 High High
Bioavailability 6 67.96 Quite High
Potency 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 18 99.24 Very High Very High Very High
Shock 1 98.64 Very High Very High Very High
Fever 8 93.20 High High
Dengue 2 91.88 High High
Flavivirus Infection 1 90.96 High High
Headache 2 86.64 High High
Cancer 47 85.84 High High
Fatigue 10 85.84 High High
Apoptosis 13 84.92 Quite High
Pain 1 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The polypeptide is post-translationally cleaved into ten distinct proteins including three structural proteins; capsid (C) protein, envelope (E) protein, and pre-membrane (prM) protein, and seven non-structural (NS) proteins; NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 [1].
Protein_catabolism (cleaved) of NS5
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.99 Pain Relevance 0.09
They have been extensively studied for their ability to induce acetylation and to inhibit the ATP binding and chaperone function of heat shock protein (HSP) 90, promoting the polyubiquitylation and proteasomal degradation of the pro-growth and prosurvival client proteins Bcr-Abl, mutant FLT-3, c-Raf, and AKT in human leukemia cells [123].
Protein_catabolism (degradation) of c-Raf associated with leukemia and shock
2) Confidence 0.03 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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