INT284989

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.64
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (INTS2) intracellular (INTS2)
INTS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 94.24 High High
palliative 1 63.68 Quite High
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 138 99.66 Very High Very High Very High
Disease 27 99.30 Very High Very High Very High
Death 8 95.88 Very High Very High Very High
Carcinoma 7 94.68 High High
INFLAMMATION 2 94.24 High High
Breast Cancer 123 92.24 High High
Fatigue 9 76.48 Quite High
Targeted Disruption 6 75.64 Quite High
Myelodysplastic Syndromes 58 72.60 Quite High
Myeloid Leukemia 46 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ER/PR-negative tumors are often associated with aggressive disease, and these tumors frequently show amplification of HER2, c-Myc, and Int2 oncogenes, and mutations of the p53 tumor suppressor gene.
Localization (amplification) of Int2 associated with cancer and disease
1) Confidence 0.43 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.13 Pain Relevance 0.11
Responses were observed in both low/int-1 as well as int-2/high IPSS score patients and they were associated to longer median time to leukemic transformation or death (21 months for azacitidine versus 13 months for supportive care) [69].
Localization (observed) of int-2 associated with death
2) Confidence 0.05 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.50 Pain Relevance 0

General Comments

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