INT284992

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HDAC8) nucleus (HDAC8) transcription factor binding (HDAC8)
cytoplasm (HDAC8)
Anatomy Link Frequency
HeLa 1
HDAC8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 12 82.28 Quite High
anticonvulsant 2 5.56 Low Low
Potency 8 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 94 90.68 High High
Hematologic Neoplasms 12 90.40 High High
Apoptosis 26 85.28 High High
Leukemia 36 84.80 Quite High
Cv General 2 Under Development 2 80.20 Quite High
Anorexia 14 79.64 Quite High
Volume Depletion And Dehydration 4 79.24 Quite High
Dysgeusia 2 78.72 Quite High
Vomiting 40 78.28 Quite High
Fatigue 18 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M concentration complete inhibition of HeLa nuclear extract HDAC activity as well as recombinant HDAC1, 3, 6 and 8, although the inhibition of HDAC8 was significantly weaker [88].
Negative_regulation (inhibition) of HDAC8 in HeLa
1) Confidence 0.21 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.88 Pain Relevance 0
M concentrations are requested to inhibit HDAC8 [88] (Table 2).
Negative_regulation (inhibit) of HDAC8
2) Confidence 0.18 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.49 Pain Relevance 0.04

General Comments

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