INT285

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Context Info
Confidence 0.68
First Reported 1975
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 73
Total Number 76
Disease Relevance 61.47
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 8
upper 5
erythrocyte 3
skeleton 1
central nervous system 1
Salpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 30 99.96 Very High Very High Very High
halothane 2 99.92 Very High Very High Very High
Pain 58 99.90 Very High Very High Very High
Paracetamol 7 99.76 Very High Very High Very High
Crohn's disease 10 99.62 Very High Very High Very High
depression 7 99.58 Very High Very High Very High
Arthritis 3 99.44 Very High Very High Very High
Central nervous system 7 99.34 Very High Very High Very High
alcohol 3 99.12 Very High Very High Very High
Chronic pancreatitis 5 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Abdominal Pain 30 99.96 Very High Very High Very High
Fever 30 99.96 Very High Very High Very High
Rickets 29 99.92 Very High Very High Very High
Inflammatory Bowel Disease 19 99.92 Very High Very High Very High
Pain 37 99.90 Very High Very High Very High
Thyroiditis 22 99.90 Very High Very High Very High
Leukocytosis 5 99.90 Very High Very High Very High
Hyperamylasemia 1 99.90 Very High Very High Very High
Pancreatitis 21 99.88 Very High Very High Very High
Weight Loss 6 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum alkaline phosphatase activity increased 2.5 times the upper normal level, up to the 5th month and then declined to normal levels up the 12th month (p < 0.05).
Positive_regulation (increased) of Serum alkaline phosphatase in upper
1) Confidence 0.68 Published 1993 Journal Am. J. Nephrol. Section Abstract Doc Link 8322836 Disease Relevance 0.53 Pain Relevance 0.09
RESULTS: All patients presented with severe right upper quadrant and/or mid-epigastric abdominal pain and had marked elevations of serum alkaline phosphatase.
Positive_regulation (elevations) of serum alkaline phosphatase in upper
2) Confidence 0.68 Published 1995 Journal Am. J. Med. Section Body Doc Link 7503081 Disease Relevance 0.14 Pain Relevance 0
Serum alkaline phosphatase was elevated in 81% of the cases.
Positive_regulation (elevated) of Serum alkaline phosphatase
3) Confidence 0.67 Published 1979 Journal Acta Med Scand Section Abstract Doc Link 393082 Disease Relevance 1.07 Pain Relevance 0.15
Both involved homosexual men who presented with right upper quadrant pain and elevations of serum alkaline phosphatase and bilirubin.
Positive_regulation (elevations) of serum alkaline phosphatase in upper associated with pain
4) Confidence 0.66 Published 1989 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 2535776 Disease Relevance 0.98 Pain Relevance 0.10
They had hypocalcaemia, hypophosphataemia, hypocalciuria and increased serum alkaline phosphatase, but only phosphataemia was significantly lower than in non-osteomalacia patients.
Positive_regulation (increased) of serum alkaline phosphatase associated with hypocalcemia, rickets and hypophosphatemia
5) Confidence 0.66 Published 1985 Journal Presse Med Section Abstract Doc Link 2933667 Disease Relevance 1.13 Pain Relevance 0.16
Recognition of an increased level of serum alkaline phosphatase and hypophosphatemia led to the diagnosis of osteomalacia.
Positive_regulation (increased) of serum alkaline phosphatase associated with rickets and hypophosphatemia
6) Confidence 0.66 Published 1994 Journal Muscle Nerve Section Abstract Doc Link 8196699 Disease Relevance 1.08 Pain Relevance 0.23
A 23-year-old black woman presented with abdominal pain of sudden onset, high fever, chills, and an elevated serum alkaline phosphatase level.
Positive_regulation (elevated) of serum alkaline phosphatase associated with abdominal pain, chills and fever
7) Confidence 0.66 Published 1997 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 8986536 Disease Relevance 0.85 Pain Relevance 0.10
Erythrocyte sedimentation rate and serum alkaline phosphatase levels were elevated in all subjects.
Positive_regulation (elevated) of serum alkaline phosphatase in Erythrocyte
8) Confidence 0.66 Published 1999 Journal Spinal Cord Section Abstract Doc Link 10025695 Disease Relevance 1.39 Pain Relevance 0.17
Although an elevation of serum alkaline phosphatase was observed in our case, results of laboratory tests were mostly of no diagnostic significance.
Positive_regulation (elevation) of serum alkaline phosphatase
9) Confidence 0.66 Published 1988 Journal J Craniomaxillofac Surg Section Abstract Doc Link 3049678 Disease Relevance 0.82 Pain Relevance 0.11
In contrast to what has been found in adult studies, serum alkaline phosphatase was not elevated during heterotopic ossification formation.
Neg (not) Positive_regulation (elevated) of serum alkaline phosphatase associated with heterotopic ossification
10) Confidence 0.66 Published 2000 Journal J. Child Neurol. Section Abstract Doc Link 10868785 Disease Relevance 1.63 Pain Relevance 0.18
The serum alkaline phosphatase and urinary hydroxyproline are variably elevated, while other biochemical indices are normal.
Positive_regulation (elevated) of serum alkaline phosphatase
11) Confidence 0.66 Published 1988 Journal J Bone Joint Surg Br Section Abstract Doc Link 3346299 Disease Relevance 0.79 Pain Relevance 0.10
An elevated serum alkaline phosphatase level was the most frequent abnormal laboratory finding.
Positive_regulation (elevated) of serum alkaline phosphatase
12) Confidence 0.66 Published 1984 Journal Arch Surg Section Abstract Doc Link 6712475 Disease Relevance 0.51 Pain Relevance 0.35
Impressive bone-marrow oedema on MRI as well as elevated serum alkaline phosphatase was seen in all patients, and often exceeded the duration of clinical symptoms.
Positive_regulation (elevated) of serum alkaline phosphatase
13) Confidence 0.66 Published 2000 Journal Nephrol. Dial. Transplant. Section Body Doc Link 11071978 Disease Relevance 0 Pain Relevance 0
Liver abscess should be suspected in patients with regional enteritis who present with fever, elevated serum alkaline phosphatase, liver tenderness, right upper quadrant pain or hepatomegaly.
Positive_regulation (elevated) of serum alkaline phosphatase in Liver associated with pain, inflammatory bowel disease, liver abscess, hepatomegaly and fever
14) Confidence 0.66 Published 1979 Journal Am. J. Gastroenterol. Section Abstract Doc Link 507033 Disease Relevance 0.83 Pain Relevance 0.10
ESR and serum alkaline phosphatase levels were elevated in all but one subject.
Positive_regulation (elevated) of serum alkaline phosphatase
15) Confidence 0.66 Published 2001 Journal Neurol India Section Abstract Doc Link 11303239 Disease Relevance 1.74 Pain Relevance 0.14
A persistent elevation of the level of serum alkaline phosphatase or more overt clinical manifestations, such as pain in the right upper quadrant, hepatomegaly, obstructive jaundice or weight loss, would all indicate the need for further investigations.
Spec (investigations) Positive_regulation (elevation) of serum alkaline phosphatase in upper associated with pain, weight loss, hepatomegaly and obstructive jaundice
16) Confidence 0.66 Published 1985 Journal Surg Gynecol Obstet Section Abstract Doc Link 3881836 Disease Relevance 0.86 Pain Relevance 0.18
All were osteopenic or osteoporotic with hypocalcemia, very low or undetectable 25-hydroxyvitamin D levels, secondary hyperparathyroidism, increased 1,25-dihydroxyvitamin D levels, and increased serum alkaline phosphatase.
Positive_regulation (increased) of serum alkaline phosphatase
17) Confidence 0.66 Published 2005 Journal Am. J. Med. Sci. Section Body Doc Link 15711420 Disease Relevance 0 Pain Relevance 0
Elevation of the level of serum alkaline phosphatase appears to be the most useful and consistent biochemical indicator of hepatic dysfunction (101).
Positive_regulation (Elevation) of serum alkaline phosphatase associated with hepatotoxicity
18) Confidence 0.66 Published 1985 Journal Surg Gynecol Obstet Section Abstract Doc Link 3881836 Disease Relevance 0.72 Pain Relevance 0.16
For this group of 30, the main problem was fever in 12 patients, anorexia, weight loss, and elevated serum alkaline phosphatase level suggesting an occult malignancy in 7, and unexplained anemia in 3.
Positive_regulation (elevated) of serum alkaline phosphatase associated with appetite loss, malignant neoplastic disease, anaemia, weight loss and fever
19) Confidence 0.66 Published 1980 Journal Arthritis Rheum. Section Abstract Doc Link 7387740 Disease Relevance 1.37 Pain Relevance 0.08
We conclude that since the marrow infiltration can be subtle, marrow smears should be carefully scrutinized for tumour cells in patients with leukoerythroblastic blood picture, in particular those with an elevated serum alkaline phosphatase level.
Positive_regulation (elevated) of serum alkaline phosphatase in blood associated with cancer
20) Confidence 0.49 Published 1993 Journal Hematol Oncol Section Abstract Doc Link 8325625 Disease Relevance 1.03 Pain Relevance 0.06

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