INT285006

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.11
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) aging (Casp7)
cytoplasm (Casp7)
Anatomy Link Frequency
hepatocytes 1
Casp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 114 99.36 Very High Very High Very High
Inflammation 18 80.08 Quite High
cytokine 6 46.24 Quite Low
anesthesia 9 18.08 Low Low
depression 2 5.64 Low Low
cva 24 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 49 99.36 Very High Very High Very High
Apoptosis 105 97.92 Very High Very High Very High
Hypothermia 138 97.52 Very High Very High Very High
Cv General 4 Under Development 13 93.52 High High
Retina Disease 51 93.28 High High
Ocular Hypertension 24 91.08 High High
Death 30 90.48 High High
Hypoxia 12 80.80 Quite High
INFLAMMATION 21 80.08 Quite High
Hemorrhagic Shock 18 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it seems likely that the absence of caspase-7 upregulation is a consequence of the regulation of caspase-3.
Positive_regulation (upregulation) of caspase-7
1) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.70 Pain Relevance 0.17
We also showed that caspase mRNA was specifically modulated by ischemia, as we reported a time-related increase in caspase-3 and decrease in caspase-7.
Positive_regulation (increase) of caspase-7 associated with ischemia
2) Confidence 0.17 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.78 Pain Relevance 0.15
At 24 h post I/R, caspase-7 was further reduced (0.536±0.025, p<0.005) while caspase-3 was upregulated (1.656±0.141, p<0.05) (Figure 6A-D).
Positive_regulation (upregulated) of caspase-7
3) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.57 Pain Relevance 0.13
Moderate hypothermia has been shown to suppress Fas-mediated apoptosis in stored cultured hepatocytes, along with suppression of cytochrome-c release from mitochondria and downstream activation of caspase-7 and caspase-9 [103].
Positive_regulation (activation) of caspase-7 in hepatocytes associated with hypothermia and apoptosis
4) Confidence 0.04 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.06 Pain Relevance 0.22

General Comments

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