INT285067

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) extracellular space (CCL16) signal transduction (ITK)
extracellular region (CCL16) cell-cell signaling (CCL16) cytoplasm (ITK)
ITK (Homo sapiens)
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 55.84 Quite High
COX-2 inhibitor 22 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 2 98.04 Very High Very High Very High
Injury 6 92.56 High High
Apoptosis 32 88.56 High High
Cataract 62 82.44 Quite High
Capsule Opacification 114 79.72 Quite High
Cancer 12 74.96 Quite High
Endophthalmitis 4 49.84 Quite Low
Retina Disease 6 48.44 Quite Low
Macular Edema 4 47.64 Quite Low
Ocular Hypertension 2 46.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While our study did not examine the specific mechanism through which celecoxib exerts its effects on cell-cycle regulation, we have provided evidence that EMT-like changes in LEC are inhibited by celecoxib at least in part through decreased cellular proliferation.
Negative_regulation (inhibited) of EMT-like Regulation (changes) of LEC associated with hyperplasia
1) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.69 Pain Relevance 0.03
To determine if COX-2 inhibition would prevent EMT-like changes in LEC, we allowed primary cultures of normal canine LEC to grow to 95% confluence.
Negative_regulation (prevent) of EMT-like Regulation (changes) of LEC
2) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.41 Pain Relevance 0

General Comments

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