INT285068

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) extracellular space (CCL16) signal transduction (ITK)
extracellular region (CCL16) cell-cell signaling (CCL16) cytoplasm (ITK)
ITK (Homo sapiens)
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 55.84 Quite High
COX-2 inhibitor 33 5.00 Very Low Very Low Very Low
diclofenac 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 3 97.48 Very High Very High Very High
Capsule Opacification 171 96.96 Very High Very High Very High
Injury 9 92.56 High High
Apoptosis 48 87.44 High High
Cataract 93 85.96 High High
Cancer 18 74.96 Quite High
Toxicity 27 64.40 Quite High
Endophthalmitis 6 49.84 Quite Low
Retina Disease 9 48.44 Quite Low
Macular Edema 6 47.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While our study did not examine the specific mechanism through which celecoxib exerts its effects on cell-cycle regulation, we have provided evidence that EMT-like changes in LEC are inhibited by celecoxib at least in part through decreased cellular proliferation.
EMT-like Regulation (changes) of LEC associated with hyperplasia
1) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.69 Pain Relevance 0.03
and EGF signaling pathways are sufficient to induce EMT-like changes in LEC, and these pathways have been shown to be involved in cataractogenesis and PCO formation [18,47-51].
EMT-like Regulation (changes) of LEC associated with capsule opacification
2) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.76 Pain Relevance 0
To determine if COX-2 inhibition would prevent EMT-like changes in LEC, we allowed primary cultures of normal canine LEC to grow to 95% confluence.
EMT-like Regulation (changes) of LEC
3) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.41 Pain Relevance 0

General Comments

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