INT28507

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Context Info
Confidence 0.26
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.84
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1 90.16 High High
tolerance 2 86.72 High High
Enkephalin 3 75.00 Quite High
Angina 1 75.00 Quite High
pruritus 1 56.32 Quite High
corticosteroid 1 53.44 Quite High
Analgesic 1 52.00 Quite High
Antihistamine 2 49.52 Quite Low
Bile 1 48.08 Quite Low
Opioid 1 47.76 Quite Low
Disease Link Frequency Relevance Heat
Pyelonephritis 30 100.00 Very High Very High Very High
Gallstones 2 93.80 High High
Hepatotoxicity 2 93.08 High High
Liver Disease 2 91.76 High High
Obstructive Jaundice 4 90.24 High High
Cv General 3 Under Development 1 90.16 High High
Jaundice 5 84.76 Quite High
Asthenozoospermia 2 75.52 Quite High
Angina 1 75.00 Quite High
Urinary Tract Infection 32 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the results of the present study indicate that alterations in the activity of aminopeptidase N may be one of the molecular components that contribute to male human subfertility.
Regulation (alterations) of aminopeptidase N
1) Confidence 0.26 Published 2004 Journal J. Androl. Section Abstract Doc Link 15292103 Disease Relevance 0.21 Pain Relevance 0.19
Based on proposed mechanisms, concomitant use of drugs that alter microsomal hepatic enzyme function or have metabolic pathways that interfere with or overlap with those of the phenothiazines could be expected to potentiate or reduce the risk of cholestasis.
Regulation (alter) of microsomal hepatic enzyme associated with gallstones
2) Confidence 0.19 Published 1987 Journal Clin Pharm Section Abstract Doc Link 2905941 Disease Relevance 1.22 Pain Relevance 0.11
The promoter sequences from extracted chromosomal DNA derived from APN and ABU patients were PCR-amplified using the Infusion primers 5?
Regulation (derived) of APN associated with pyelonephritis
3) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.24 Pain Relevance 0
In addition, the effect of nifedipin treatment on nonspecific microsomal hepatic oxidase activity was assessed by means of the antipyrin test.
Regulation (effect) of microsomal hepatic oxidase
4) Confidence 0.02 Published 1989 Journal Kardiologiia Section Abstract Doc Link 2770079 Disease Relevance 0.17 Pain Relevance 0.21

General Comments

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