INT28516

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 1.08
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pmch) nucleus (Pmch)
Anatomy Link Frequency
neurons 5
body 2
melanophore 1
Pmch (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 5 100.00 Very High Very High Very High
Cannabinoid 12 99.70 Very High Very High Very High
Neuropeptide 47 99.22 Very High Very High Very High
antagonist 10 97.48 Very High Very High Very High
Cholecystokinin 2 97.48 Very High Very High Very High
Ventral tegmentum 10 94.28 High High
tetrodotoxin 6 92.64 High High
Opioid 3 92.56 High High
agonist 6 89.32 High High
Glutamate 4 88.40 High High
Disease Link Frequency Relevance Heat
Body Weight 13 100.00 Very High Very High Very High
Targeted Disruption 4 95.40 Very High Very High Very High
Anxiety Disorder 2 86.92 High High
Cognitive Disorder 2 75.00 Quite High
Neurological Disease 2 71.32 Quite High
Sleep Disorders 4 29.92 Quite Low
Hyperphagia 1 25.44 Quite Low
Obesity 2 24.16 Low Low
Infection 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-expressing transgenic mice.
Regulation (effect) of melanin-concentrating hormone in neurons associated with targeted disruption and glutamate receptor
1) Confidence 0.45 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.10 Pain Relevance 0.20
We used single-unit extracellular and whole-cell patch-clamp recordings to examine the effects of orexins (A and B) and melanin-concentrating hormone (MCH) on neurons in this region.
Spec (examine) Regulation (effects) of melanin-concentrating hormone in neurons
2) Confidence 0.44 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514194 Disease Relevance 0.09 Pain Relevance 0.31
We used single-unit extracellular and whole-cell patch-clamp recordings to examine the effects of orexins (A and B) and melanin-concentrating hormone (MCH) on neurons in this region.
Spec (examine) Regulation (effects) of MCH in neurons
3) Confidence 0.44 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514194 Disease Relevance 0.09 Pain Relevance 0.31
The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-expressing transgenic mice.
Regulation (effect) of MCH in neurons associated with targeted disruption and glutamate receptor
4) Confidence 0.39 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.10 Pain Relevance 0.20
Together, these results show that cannabinoids have opposite effects on MCH and hypocretin neurons.
Regulation (effects) of MCH in neurons associated with cannabinoid
5) Confidence 0.39 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17475795 Disease Relevance 0.07 Pain Relevance 0.66
Verapamil diminished the sensitivity to MCH5-17, but did not affect melanophore responses to MCH or MCH1-14.
Neg (not) Regulation (affect) of MCH in melanophore
6) Confidence 0.36 Published 1989 Journal Pigment Cell Res. Section Abstract Doc Link 2771878 Disease Relevance 0 Pain Relevance 0.13
In this overview, an introduction to the GPCRs and the field of central regulation of food intake is provided together with brief mentioning of some other GPCRs that are also implicated in regulation of body weight, such as the melanin-concentrating hormone (MCH), neuromedin U, prolactin-releasing peptide (PrRP), bombesin, cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1) (and oxyntomodulin), neuropeptide B (NPB) and neuropeptide W (NPW), opioids peptides, free fatty acid (FFA) receptors (GPR40, GPR41).
Regulation (regulation) of melanin-concentrating hormone in body associated with body weight, neuropeptide, opioid and cholecystokinin
7) Confidence 0.05 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16787226 Disease Relevance 0.32 Pain Relevance 0.36
In this overview, an introduction to the GPCRs and the field of central regulation of food intake is provided together with brief mentioning of some other GPCRs that are also implicated in regulation of body weight, such as the melanin-concentrating hormone (MCH), neuromedin U, prolactin-releasing peptide (PrRP), bombesin, cholecystokinin (CCK), Glucagon-like peptide-1 (GLP-1) (and oxyntomodulin), neuropeptide B (NPB) and neuropeptide W (NPW), opioids peptides, free fatty acid (FFA) receptors (GPR40, GPR41).
Regulation (regulation) of MCH in body associated with body weight, neuropeptide, opioid and cholecystokinin
8) Confidence 0.05 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16787226 Disease Relevance 0.32 Pain Relevance 0.36
Numerous neuropeptide precusors have been implicated in the regulation of energy balance, such as pro-opiomelanocortin (POMC), melanin concentrating hormone (MCH) and ghrelin.
Regulation (regulation) of MCH associated with neuropeptide
9) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.30

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