INT285165

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.58

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MIR377 (Homo sapiens)
Pain Link Frequency Relevance Heat
HCN1 230 82.04 Quite High
hCN2 40 56.72 Quite High
addiction 5 5.00 Very Low Very Low Very Low
local anesthetic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 10 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Hypertrophy 5 5.00 Very Low Very Low Very Low
Myocardial Infarction 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, whereas M377 and F378 negatively interact with other in drug binding, the interaction between residues F378 and V379 is positive.
M377 Binding (interact) of
1) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.12
This spatial arrangement is consistent with our thermodynamic cycle analysis that energetic interactions exist only for the pairs M377–F378 and F378–V379 but not M377–V379.
M377 Binding (interactions) of
2) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.08
This spatial arrangement is consistent with our thermodynamic cycle analysis that energetic interactions exist only for the pairs M377–F378 and F378–V379 but not M377–V379.
M377 Binding (interactions) of
3) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.08
Furthermore, thermodynamic cycle analysis revealed that the pairs M377–F378 and F378–V379, but not M377–V379, energetically interact.
M377 Binding (interact) of
4) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.15
Furthermore, thermodynamic cycle analysis revealed that the pairs M377–F378 and F378–V379, but not M377–V379, energetically interact.
M377 Binding (interact) of
5) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.15

General Comments

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