INT285165

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 0 Pain Relevance 0.58

MIR377 (Homo sapiens)

Pain Link Frequency Relevance Heat HCN1 230 82.04 hCN2 40 56.72 addiction 5 5.00 local anesthetic 5 5.00

Disease Link Frequency Relevance Heat Heart Rate Under Development 10 5.00 Hypertension 5 5.00 Hypertrophy 5 5.00 Myocardial Infarction 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, whereas M377 and F378 negatively interact with other in drug binding, the interaction between residues F378 and V379 is positive.

M377 Binding (interact) of

1) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.12

This spatial arrangement is consistent with our thermodynamic cycle analysis that energetic interactions exist only for the pairs M377–F378 and F378–V379 but not M377–V379.

M377 Binding (interactions) of

2) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.08

This spatial arrangement is consistent with our thermodynamic cycle analysis that energetic interactions exist only for the pairs M377–F378 and F378–V379 but not M377–V379.

M377 Binding (interactions) of

3) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.08

Furthermore, thermodynamic cycle analysis revealed that the pairs M377–F378 and F378–V379, but not M377–V379, energetically interact.

M377 Binding (interact) of

4) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.15

Furthermore, thermodynamic cycle analysis revealed that the pairs M377–F378 and F378–V379, but not M377–V379, energetically interact.

M377 Binding (interact) of

5) Confidence 0.00 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765624 Disease Relevance 0 Pain Relevance 0.15

General Comments

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