INT285182

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn1)
Accn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 36 100.00 Very High Very High Very High
qutenza 144 91.00 High High
Calcitonin gene-related peptide 12 13.44 Low Low
Pain 12 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
tissue acidosis 4 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 282 93.28 High High
Hypoxia 124 89.88 High High
Cv Unclassified Under Development 36 56.44 Quite High
Pain 12 5.00 Very Low Very Low Very Low
Acid Base Imbalance 10 5.00 Very Low Very Low Very Low
Lactic Acidosis 10 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ASIC channels are widely reported to be inhibited by amiloride [106] although this is not entirely selective as amiloride may also inhibit T-type voltage-gated Ca2+ channels [86, 95].
Negative_regulation (inhibited) of ASIC associated with asic
1) Confidence 0.04 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.37 Pain Relevance 0.14
There are a number of possible explanations for this: Firstly, intrinsic inactivation leads to rapid (seconds) decline in ASIC activity [42, 78], secondly, elevated intracellular calcium leads to inactivation of TRPV1, and finally, declining ATP levels may contribute to loss of TRPV1 activity [91, 94, 112].
Negative_regulation (decline) of ASIC associated with asic
2) Confidence 0.04 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.69 Pain Relevance 0.17

General Comments

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