INT285203

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 0.64
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
external 1
PC-3 1
Hts (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 121 90.16 High High
Potency 42 58.24 Quite High
Glutamate 15 50.00 Quite Low
fluoxetine 216 31.68 Quite Low
Eae 8 25.96 Quite Low
Endep 136 5.00 Very Low Very Low Very Low
Hippocampus 96 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Bioavailability 30 5.00 Very Low Very Low Very Low
antidepressant 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 73 96.20 Very High Very High Very High
Recurrence 8 46.72 Quite Low
Leishmaniasis 100 26.68 Quite Low
Disease 28 14.04 Low Low
Toxicity 41 5.00 Very Low Very Low Very Low
Infection 20 5.00 Very Low Very Low Very Low
Congenital Anomalies 16 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 15 5.00 Very Low Very Low Very Low
Schizophrenia 13 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we would point out that HTS produces transcript frequency estimates that range over approximately five orders of magnitude, in contrast to LTS, where the estimates range over one order of magnitude.
Gene_expression (produces) of HTS
1) Confidence 0.55 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.14 Pain Relevance 0
The LTS and HTS approaches produce comparable estimates of editing frequencies by site.
Gene_expression (approaches) of HTS
2) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.17 Pain Relevance 0
Multiplexing HTS technology to simplify the measurement of 5-HT2C RNA editing under different experimental conditions
Gene_expression (technology) of HTS
3) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0.05
Comparison of results obtained by LTS and HTS
Gene_expression (obtained) of HTS
4) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.07 Pain Relevance 0
Two-way ANOVA analysis of the HTS data shows no effect of genotype on transcript frequency (P = 0.9867), which is confirmed by Bonferroni post-tests.
Gene_expression (analysis) of HTS
5) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.19 Pain Relevance 0
Furthermore, the Genome Analyzer II, on which our HTS experiment was performed, is amenable to multiplexing 26 or more samples in each lane of a flow cell, which cuts the cost per experiment by an order of magnitude, making RNA editing analysis by HTS considerably less expensive on a per animal basis than RNA editing analysis by LTS.
Gene_expression (experiment) of HTS
6) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0
(B) Ultra HTS sequencing produced 22 652 442/122 828 564 sequences.
Gene_expression (sequencing) of HTS
7) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0
In parallel with our ultra HTS experiment, we also measured 5-HT2C RNA editing by the most common LTS approach to provide a realistic comparison of findings (24).
Gene_expression (experiment) of HTS
8) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.07 Pain Relevance 0
In conclusion, machine learning methods (ANN) were used to generate QSAR models from an HTS experimental data set in virtual screens of an external commercial compound collection for the purpose of enrichment of our local library for compounds with mGluR5 allosteric activity.
Gene_expression (experimental) of HTS in external
9) Confidence 0.39 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0.03
The selected assay detection reagent, alamar blue, is simple, inexpensive, easily adapted to automated HTS procedures and has been frequently used to identify and characterize leishmanicidal compounds [43],[44].
Gene_expression (procedures) of HTS
10) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0
For automated HTS procedures, L. major promastigotes (5,000 parasites/22 ┬ÁL) in complete growth medium were seeded into each well of the microtiter plates using a MAPC2 bulk dispenser (Titertek, Huntsville, AL).
Gene_expression (procedures) of HTS
11) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0
Briefly, for automated HTS procedures, cells (A549, IMR-90 and, HeLa, 1,000 cells; PC-3, 750 cells and; MDA-MB-231, 3,000 cells) in complete culture medium were seeded into each well of 384-well microtiter plates using a Titertek MAPC-2 bulk dispenser.
Gene_expression (procedures) of HTS in PC-3
12) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0
For HTS assays, L. major promastigote cultures were harvested during exponential growth phase (?
Gene_expression (assays) of HTS
13) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0.03
HTS data analysis, computational filtering, and statistical analysis
Gene_expression (analysis) of HTS
14) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0 Pain Relevance 0

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