INT28521

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 56
Total Number 58
Disease Relevance 16.62
Pain Relevance 8.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
blood 6
plasma 3
coronary artery 1
erythrocytes 1
impression 1
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 99 99.82 Very High Very High Very High
lidocaine 81 99.62 Very High Very High Very High
Paracetamol 39 99.56 Very High Very High Very High
local anesthetic 97 99.44 Very High Very High Very High
cINOD 6 97.68 Very High Very High Very High
cva 39 95.84 Very High Very High Very High
anesthesia 148 95.28 Very High Very High Very High
Central nervous system 9 94.56 High High
ketamine 45 94.16 High High
Angina 4 89.76 High High
Disease Link Frequency Relevance Heat
Methemoglobinemia 421 99.84 Very High Very High Very High
Toxicity 104 99.80 Very High Very High Very High
Pressure And Volume Under Development 48 99.34 Very High Very High Very High
Cyanosis 106 99.32 Very High Very High Very High
Hypoxia 26 99.04 Very High Very High Very High
Cv Unclassified Under Development 16 99.02 Very High Very High Very High
Anaemia 34 98.84 Very High Very High Very High
Coronary Artery Disease 3 98.48 Very High Very High Very High
Delirium 2 97.60 Very High Very High Very High
Confusion 2 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methemoglobin levels produced by organic nitrates in patients with coronary artery disease.
Gene_expression (produced) of Methemoglobin in coronary artery associated with coronary artery disease
1) Confidence 0.77 Published 1984 Journal J Clin Pharmacol Section Title Doc Link 6427300 Disease Relevance 0.37 Pain Relevance 0.18
Pulse oximeters do not detect methemoglobin and the distinction of hypoxia and methemoglobin is not possible, which may give a false impression of patient oxygenation.
Neg (not) Gene_expression (detect) of methemoglobin in impression associated with hypoxia
2) Confidence 0.75 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.92 Pain Relevance 0.18
Patients with anemia or cardiorespiratory problems should be treated at lower levels of methemoglobin.
Gene_expression (levels) of methemoglobin associated with anaemia
3) Confidence 0.75 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.88 Pain Relevance 0
This is due to the inactivation of NO as it reacts with hemoglobin (producing methemoglobin) and oxygen dissolved in plasma.
Gene_expression (producing) of hemoglobin in plasma
4) Confidence 0.72 Published 2008 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2700444 Disease Relevance 0.42 Pain Relevance 0
Methemoglobin levels did not exceed normal values (1.5%) in any patient, and there was no relationship between methemoglobin levels and patient weight, amount of EC used, measured peak plasma concentration, or times to measured peak concentrations of prilocaine or lidocaine.
Gene_expression (levels) of methemoglobin in plasma associated with lidocaine
5) Confidence 0.67 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11004069 Disease Relevance 0 Pain Relevance 0.34
Meta-analytic techniques revealed that methemoglobin concentrations did not differ between EMLA-treated and placebo-treated infants (weighted mean di


Gene_expression (concentrations) of methemoglobin
6) Confidence 0.66 Published 1998 Journal Pediatrics Section Body Doc Link 9445511 Disease Relevance 0 Pain Relevance 0
The results of final arterial blood gas analysis were a methemoglobin level of 0.4% and a carboxyhemoglobin level of 0.8%.
Gene_expression (level) of methemoglobin in blood
7) Confidence 0.66 Published 2005 Journal J Anesth Section Abstract Doc Link 16261475 Disease Relevance 0.50 Pain Relevance 0.07
However, methemoglobin concentrations and hemoglobin levels were comparable between the two groups at all time intervals, and none of the patients demonstrated clinical symptoms.
Gene_expression (concentrations) of methemoglobin
8) Confidence 0.66 Published 2008 Journal Middle East J Anesthesiol Section Body Doc Link 18637601 Disease Relevance 0 Pain Relevance 0
Under physiological conditions, there is a slow, constant loss of electrons to release oxygen and the ferric (Fe3+) form combines with water, producing methemoglobin.
Gene_expression (producing) of methemoglobin
9) Confidence 0.65 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.53 Pain Relevance 0.78
The predominant intracellular mechanism for the reduction of methemoglobin is cytochrome b5, and only 1 to 2% of hemoglobin is normally in the ferric state.
Gene_expression (reduction) of methemoglobin
10) Confidence 0.65 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.58 Pain Relevance 0.70
Cyanosis is the first clinical event when methemoglobin levels reach ?
Gene_expression (levels) of methemoglobin associated with cyanosis
11) Confidence 0.65 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.81 Pain Relevance 0.23
The results of the current study did not indicate higher methemoglobin levels in women who reported eating cured meats or vegetables that are potentially high in nitrates in the 24 hours before testing (Tables 5 and 7).
Gene_expression (levels) of methemoglobin
12) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
At enrollment, higher methemoglobin levels were observed in women who reported using tap water at home for drinking and cooking (0.77 ± 0.49), compared to women using bottled water (0.66 ± 0.47) (p = 0.04).
Gene_expression (levels) of methemoglobin
13) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
Methemoglobin levels at 36 weeks gestation were higher among women with intermediate range of tap water nitrate levels compared to women with ?
Gene_expression (levels) of Methemoglobin
14) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
The current study result of decreasing methemoglobin levels during pregnancy did not support the a priori hypothesis that methemoglobin levels increase during pregnancy in populations exposed to nitrates in drinking water.
Gene_expression (levels) of methemoglobin
15) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.06 Pain Relevance 0
Subclinical increases in methemoglobin levels may occur in populations exposed to low levels of nitrates in drinking water; however, methemoglobin levels in these populations have not been well characterized.
Gene_expression (levels) of methemoglobin
16) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.39 Pain Relevance 0.06
Although the beta estimate from the multi-variable regression assessment of methemoglobin levels at 36 weeks was suggestive of higher methemoglobin levels among pregnant women with higher estimated nitrate intake from tap water, it was not statistically significant (?
Gene_expression (levels) of methemoglobin
17) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
At all follow up time points less than 1% of pregnant women tested had methemoglobin levels above the physiologic normal of 2% total hemoglobin (Table 4).
Gene_expression (levels) of methemoglobin
18) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0 Pain Relevance 0
Methemoglobin levels were not above the physiologic normal in the current study, and the results did not show a statistically significant association between higher methemoglobin levels in women with higher estimated nitrate intake from their tap water (Table 7).
Gene_expression (levels) of methemoglobin
19) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.08 Pain Relevance 0
Also, when the model was assessed with tap water nitrate levels as a continuous variable, there was no statistically significant association found with methemoglobin levels and nitrate levels at 36 weeks gestation among women who drank tap water at home (?
Gene_expression (levels) of methemoglobin
20) Confidence 0.65 Published 2010 Journal Environ Health Section Body Doc Link PMC2967503 Disease Relevance 0.06 Pain Relevance 0

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