INT28528

Context Info Confidence 0.65 First Reported 1989 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 25 Total Number 26 Disease Relevance 7.66 Pain Relevance 3.49

extracellular space (MSMB) extracellular region (MSMB) nucleus (MSMB) molecular_function (MSMB) biological_process (MSMB)

Anatomy Link Frequency PSP 6 MBH 1 liver 1 duct 1 MSMB (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 2 99.92 tetrodotoxin 222 99.62 sodium channel 6 97.90 metalloproteinase 2 94.16 withdrawal 8 91.36 chemokine 2 89.84 anesthesia 5 88.04 lidocaine 4 81.40 imagery 2 80.92 tolerance 2 78.44

Disease Link Frequency Relevance Heat Poisoning 75 100.00 Shellfish Poisoning 3 100.00 Pancreatitis 7 99.92 Cancer 12 99.12 Chronic Renal Failure 2 98.80 Breast Cancer 24 95.80 Malaria 280 95.56 Disease 141 95.56 Ulcers 1 94.88 Pancreatic Cancer 1 94.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PSP could not be detected in the gastric samples from children in whom the ingestion-sampling interval was more than 2.25 h.

Neg (not) Gene_expression (detected) of PSP in PSP

1) Confidence 0.65 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2774259 Disease Relevance 0.09 Pain Relevance 0.09

The MSP executive steering committee

Gene_expression (executive) of MSP

2) Confidence 0.59 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1764159 Disease Relevance 0.07 Pain Relevance 0

Additional highly expressed, androgen-regulated genes included KLK3 (PSA), MSMB (beta-microseminoprotein), ACPP (prostatic acid phosphatase) and SCGB1A1 (uteroglobin).

Gene_expression (expressed) of beta-microseminoprotein

3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.38 Pain Relevance 0.25

Serum PSP levels were significantly higher in chronic renal failure under hemodialysis (1796.0 +/- 1492.9 ng/mL) than in other diseases such as peptic ulcer, liver cirrhosis, gallstone, and diabetes mellitus.

Gene_expression (levels) of Serum PSP in liver associated with cirrhosis, chronic renal failure, diabetes mellitus, ulcers, gallstones and disease

4) Confidence 0.58 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8501356 Disease Relevance 1.24 Pain Relevance 0.19

Several mismatches to the mrtA gene sequence of Msp.stadtmanae were evident with the mcrA primer set and phylogenetic analysis and tree construction illustrates that although the mrtA gene of Msp. stadtmanae encodes an enzyme of the same function and inhabits the same niche it is phylogenetically distinct from mcrA gene sequences of Mbb. smithii and related clones (see Figure 2).

Gene_expression (stadtmanae) of Msp

5) Confidence 0.57 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.42 Pain Relevance 0

Further analysis of available 16S rRNA gene libraries from published literature [6,31] and analysis in silico of metagenomic clones libraries generated from human faecal samples also support the idea that Msp. stadtmanae is not a common feature of the human gastrointestinal microbiota.

Gene_expression (stadtmanae) of Msp

6) Confidence 0.57 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0 Pain Relevance 0

Therefore, it is quite possible that if Msp. stadtmanae was present in any of the faecal samples analysed in this study its concentration was below the detection levels of this novel primer set.

Gene_expression (present) of Msp

7) Confidence 0.50 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0 Pain Relevance 0

A second set of primers were designed and optimised for mrtA gene amplification serving as a marker for Msp. stadtmanae detection.

Gene_expression (detection) of Msp

8) Confidence 0.50 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.16 Pain Relevance 0

Additional highly expressed, androgen-regulated genes included KLK3 (PSA), MSMB (beta-microseminoprotein), ACPP (prostatic acid phosphatase) and SCGB1A1 (uteroglobin).

Gene_expression (expressed) of MSMB

9) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.37 Pain Relevance 0.24

DNA was isolated exactly as per the manufactures' instructions for both the QIAamp and PSP kits except for a 95°C lysis incubation for 5 minutes, instead of the 70°C recommended for the QIAamp kit.

Gene_expression (kits) of PSP in PSP

10) Confidence 0.28 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2921404 Disease Relevance 0 Pain Relevance 0

There were no differences among the three groups of rats during PSP in the pattern or serum PRL concentrations, and there were no significant differences among these three groups in the serum progesterone concentration or weight of the corpus luteum.

Neg (no) Gene_expression (were) of PSP in PSP

11) Confidence 0.25 Published 1998 Journal Endocr. J. Section Abstract Doc Link 9790273 Disease Relevance 0 Pain Relevance 0.22

The occurrence of calcareous red algae Jania sp. as the primary source of PSP in coral reef crabs was reported [34, 35].

Gene_expression (source) of PSP in PSP associated with poisoning

12) Confidence 0.11 Published 2010 Journal Journal of Toxicology Section Body Doc Link PMC3010647 Disease Relevance 0.70 Pain Relevance 0.18

The results also enhance the understanding of STX production and the ecology of PSP toxin-producing cyanobacteria.

Gene_expression (producing) of PSP in PSP associated with shellfish poisoning

13) Confidence 0.10 Published 2004 Journal Microbiology (Reading, Engl.) Section Abstract Doc Link 14766924 Disease Relevance 0.10 Pain Relevance 0.23

Unlike MSP, TestGraf98 produces continuous estimates of response functions ([35]; here, only the ISFs); and like MSP, TestGraf98 shows graphical displays of these estimates that can be manipulated with respect to bias and accuracy, and also here it is advisable to try several options.

Gene_expression (produces) of MSP

14) Confidence 0.09 Published 2008 Journal Qual Life Res Section Body Doc Link PMC2238782 Disease Relevance 0 Pain Relevance 0

Thus, MSP aims to produce unidimensional scales that allow accurate patient measurement.

Gene_expression (produce) of MSP

15) Confidence 0.08 Published 2008 Journal Qual Life Res Section Body Doc Link PMC2238782 Disease Relevance 0 Pain Relevance 0

CONCLUSION: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.

Gene_expression (produced) of PSP in MBH

16) Confidence 0.06 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10375763 Disease Relevance 0 Pain Relevance 0

Garter snakes and clams can also acquire similar sodium channel mutation-based TTX/PSP resistance by interacting with their toxic food organisms, TTX-bearing newts and PSP-producing dinoflagellates, respectively [92,93].

Gene_expression (producing) of PSP in PSP associated with tetrodotoxin, sodium channel and poisoning

17) Confidence 0.04 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525488 Disease Relevance 0.33 Pain Relevance 1.88

In a report by Evron et al. [15], specimens (excised tumors, duct endoscopy fluid, or DL samples) were examined by MSP for Cyclin D2, RAR-?

Spec (examined) Gene_expression (examined) of MSP in duct associated with cancer

18) Confidence 0.03 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138718 Disease Relevance 1.26 Pain Relevance 0.18

Each MSP142 protein was individually formulated on Alhydrogel (Brenntag Biosector, Denmark), an aluminum hydroxide gel, to produce the vaccines, MSP142-FVO/Alhydrogel and MSP142-3D7/Alhydrogel.

Gene_expression (produce) of MSP142-FVO

19) Confidence 0.02 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 0.43 Pain Relevance 0

The expression, refolding, and purification of E. coli-produced MSP142-FVO (lot WRAIR0997) and MSP142-3D7 (lot WRAIR0984) antigens was performed at the Walter Reed Army Institute of Research, Pilot Bioproduction Facility, Silver Spring, Maryland in accordance with current Good Manufacturing Practices (cGMP).

Gene_expression (expression) of MSP142-FVO

20) Confidence 0.02 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1847697 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

This test has worked.