INT285288

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Icam1) plasma membrane (TNF, Icam1) signal transduction (TNF)
extracellular region (TNF) cell adhesion (Icam1) intracellular (TNF)
Anatomy Link Frequency
macrophages 4
TNF (Homo sapiens)
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 26 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 6 100.00 Very High Very High Very High
Cancer 376 99.80 Very High Very High Very High
Melanoma 110 93.20 High High
Fibrosarcoma 2 50.60 Quite High
Necrosis 28 50.00 Quite Low
Sarcoma 180 4 45.36 Quite Low
Targeted Disruption 2 41.76 Quite Low
Toxicity 4 15.80 Low Low
Appetite Loss 4 10.20 Low Low
Apoptosis 16 8.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, TNF can increase the expressions of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) on tumor cells, thus increasing their vulnerability to lysis by macrophages [71].
TNF Positive_regulation (increase) of Gene_expression (expressions) of intercellular adhesion molecule 1 in macrophages associated with cancer and adhesions
1) Confidence 0.17 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766459 Disease Relevance 1.41 Pain Relevance 0
For example, TNF can increase the expressions of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) on tumor cells, thus increasing their vulnerability to lysis by macrophages [71].
TNF Positive_regulation (increase) of Gene_expression (expressions) of ICAM-1 in macrophages associated with cancer and adhesions
2) Confidence 0.17 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766459 Disease Relevance 1.42 Pain Relevance 0

General Comments

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