INT285290

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.41
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, H2-D1) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
lymphocytes 2
TNF (Homo sapiens)
H2-D1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 67.48 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 188 99.84 Very High Very High Very High
Sarcoma 180 2 89.44 High High
Toxicity 2 83.32 Quite High
Fibrosarcoma 1 79.04 Quite High
Appetite Loss 2 77.72 Quite High
Experimental Melanoma 4 60.16 Quite High
Melanoma 55 53.56 Quite High
Necrosis 14 50.00 Quite Low
Colon Cancer 1 42.04 Quite Low
Renal Cancer 1 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TNF can also indirectly suppress the activity of NK cells by, among others, stimulation of macrophages to produce prostaglandins [5, 56] and by stimulating the expression of MHC I on tumor cells, which results in a decrease in sensitivity to the anti-tumor activity of NK lymphocytes [67].
TNF Positive_regulation (stimulating) of Gene_expression (expression) of MHC I in lymphocytes associated with cancer
1) Confidence 0.01 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766459 Disease Relevance 1.41 Pain Relevance 0.06

General Comments

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