INT28532

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Context Info
Confidence 0.09
First Reported 1984
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
dendrites 1
hippocampus 1
Grhpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.58 Very High Very High Very High
Neurotransmitter 2 97.54 Very High Very High Very High
Clonidine 4 93.80 High High
tetrodotoxin 1 86.96 High High
Glutamate 2 84.12 Quite High
Central nervous system 1 75.00 Quite High
gABA 5 64.88 Quite High
agonist 1 63.84 Quite High
Dopamine 1 25.00 Low Low
Serotonin 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to the enzymatic pattern of three types of non-synaptic and synaptic mitochondria, in hippocampus a different maximum rate of both NADH-cytochrome c reductase and cytochrome oxidase was observed, these activities in particular being lowest in the "synaptic heavy" mitochondrial subfraction than in the "synaptic light" one; in addition, other enzyme activities are different in the "free" as compared to both the "light" and "heavy" mitochondria.
Localization (rate) of reductase in hippocampus associated with hippocampus
1) Confidence 0.09 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.43
gamma-Hydroxybutyrate (GHB) fulfills the main criteria of a neurotransmitter: it is unevenly distributed in C.N.S.; it is synthesized from succinic semi-aldehyde by a specific semi-aldehyde succinic reductase localized in neurons, in some dendrites and synaptic terminals; GHB is released by tissue slice depolarization, this release being reduced by 50-60% in a Ca++ free medium.
Localization (localized) of reductase in dendrites associated with neurotransmitter
2) Confidence 0.05 Published 1984 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 6145513 Disease Relevance 0 Pain Relevance 0.31

General Comments

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