INT285324

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.59 Pain Relevance 0.37

mitochondrion (Cox8b)

Anatomy Link Frequency medulla 1 CCO 1 Cox8b (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 10 99.64 Rostral ventrolateral medulla 132 99.12 medulla 10 98.76 Inflammatory response 4 5.00 Neuronal excitability 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Depression 6 99.64 Myocardial Infarction 76 96.72 Hypoxia 30 96.24 Poisoning 22 93.00 Necrosis 12 84.12 Apoptosis 4 81.44 Stress 6 72.52 Death 102 64.28 Brain Death 2 14.60 Heart Rate Under Development 20 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We reported previously [17] that the reversal by CoQ10 of Mev-induced depression in NCCR, SCCR or CCO activity or reduction in ATP level in ventrolateral medulla is accompanied by amelioration of the sustained tissue hypoxia.

Negative_regulation (reduction) of CCO in medulla associated with medulla, depression and hypoxia

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.15 Pain Relevance 0.13

Microinjection bilaterally into RVLM of CoQ10 (6 µg) significantly reversed the depressed NCCR, SCCR or CCO activity and reduced ATP production induced by 1000 µg/kg, but not 1280 µg/kg of Mev (Fig. 6).

Negative_regulation (depressed) of CCO in CCO associated with rostral ventrolateral medulla

2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

This test has worked.