INT285324

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cox8b)
Anatomy Link Frequency
medulla 1
CCO 1
Cox8b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 10 99.64 Very High Very High Very High
Rostral ventrolateral medulla 132 99.12 Very High Very High Very High
medulla 10 98.76 Very High Very High Very High
Inflammatory response 4 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 6 99.64 Very High Very High Very High
Myocardial Infarction 76 96.72 Very High Very High Very High
Hypoxia 30 96.24 Very High Very High Very High
Poisoning 22 93.00 High High
Necrosis 12 84.12 Quite High
Apoptosis 4 81.44 Quite High
Stress 6 72.52 Quite High
Death 102 64.28 Quite High
Brain Death 2 14.60 Low Low
Heart Rate Under Development 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We reported previously [17] that the reversal by CoQ10 of Mev-induced depression in NCCR, SCCR or CCO activity or reduction in ATP level in ventrolateral medulla is accompanied by amelioration of the sustained tissue hypoxia.
Negative_regulation (reduction) of CCO in medulla associated with medulla, depression and hypoxia
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.15 Pain Relevance 0.13
Microinjection bilaterally into RVLM of CoQ10 (6 µg) significantly reversed the depressed NCCR, SCCR or CCO activity and reduced ATP production induced by 1000 µg/kg, but not 1280 µg/kg of Mev (Fig. 6).
Negative_regulation (depressed) of CCO in CCO associated with rostral ventrolateral medulla
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

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