INT28533

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Context Info
Confidence 0.55
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cs) carbohydrate metabolic process (Cs)
Anatomy Link Frequency
muscle 1
Cs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 8 99.98 Very High Very High Very High
Glutamate 4 99.92 Very High Very High Very High
Hippocampus 6 80.84 Quite High
nerve block 1 50.00 Quite Low
analgesia 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 50.00 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Post Operative Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Bupivacaine caused a reduction of mitochondrial adenosine triphosphate synthesis rate, a decrease of citrate synthase activity, and muscle ultrastructural damages.
Negative_regulation (decrease) of citrate synthase in muscle
1) Confidence 0.55 Published 2009 Journal Anesthesiology Section Body Doc Link 19809284 Disease Relevance 0 Pain Relevance 0
Acute treatment with piracetam decreased citrate synthase, glutamate dehydrogenase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the "heavy" mitochondria obtained from synaptosomes.
Negative_regulation (decreased) of citrate synthase associated with glutamate
2) Confidence 0.30 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.43
Acute treatment with clonidine decreased the citrate synthase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the same type of mitochondria, i.e. synaptic "heavy" mitochondria.
Negative_regulation (decreased) of citrate synthase associated with clonidine
3) Confidence 0.30 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.48

General Comments

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