INT285337

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.93
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dhfr) mRNA binding (Dhfr)
Dhfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 55 98.08 Very High Very High Very High
Inflammation 29 92.20 High High
ischemia 1 90.44 High High
rheumatoid arthritis 3 83.12 Quite High
Inflammatory mediators 5 74.96 Quite High
cytokine 19 63.72 Quite High
fibrosis 11 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 3 99.52 Very High Very High Very High
Leukemia 1 99.16 Very High Very High Very High
Disease 3 98.40 Very High Very High Very High
INFLAMMATION 35 92.20 High High
Cv Unclassified Under Development 1 90.44 High High
Stress 1 89.76 High High
Myocardial Infarction 4 84.84 Quite High
Rheumatoid Arthritis 3 83.12 Quite High
Ventricular Remodeling 6 80.96 Quite High
Heart Rate Under Development 20 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-dose (20–250 mg/kg) methotrexate (MTX) treatment has been indicated for the treatment of neoplastic diseases, such as acute lymphoblastic leukemia and solid cancers, due to its inhibitory effect on de novo purine and pyrimidine synthesis through dihydrofolate reductase.
Regulation (effect) of Gene_expression (synthesis) of dihydrofolate reductase associated with leukemia, cancer, disease and methotrexate
1) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 1.93 Pain Relevance 0.65

General Comments

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