INT28539

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Context Info
Confidence 0.21
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.83
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Etv3) DNA binding (Etv3)
Anatomy Link Frequency
pancreas 1
arms 1
band 1
Etv3 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 99.80 Very High Very High Very High
Inflammation 28 99.00 Very High Very High Very High
Kinase C 18 93.80 High High
cytokine 4 84.16 Quite High
medulla 4 80.72 Quite High
tolerance 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 141 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 86 99.92 Very High Very High Very High
INFLAMMATION 29 99.00 Very High Very High Very High
Fatty Liver 11 96.96 Very High Very High Very High
Disease 3 95.72 Very High Very High Very High
Insulin Resistance 40 91.64 High High
Alcoholic Fatty Liver 1 77.68 Quite High
Obesity 33 77.24 Quite High
Pancreatitis 3 73.36 Quite High
Liver Disease 4 72.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HFD mouse model may promote a better experimental system in which to investigate MetS, by providing a model to examine interventions that prevent progression of fatty liver and fatty pancreas disease and to correlate the degree of liver and pancreatic steatosis with metabolic syndrome.
MetS Binding (investigate) of in pancreas associated with fatty liver, metabolic syndrome and disease
1) Confidence 0.21 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.34 Pain Relevance 0
MetS is also associated with a state of chronic inflammation.
MetS Binding (associated) of associated with inflammation and metabolic syndrome
2) Confidence 0.20 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.32 Pain Relevance 0.38
The preliminary characterization of the high molecular weight adrenomedullary pro-enk-A peptides recognized by PE-1 and PE-2 is described.
PE-1 Binding (recognized) of
3) Confidence 0.15 Published 1989 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2775454 Disease Relevance 0 Pain Relevance 0.09
Two mouse monoclonal antibodies (PE-1 and PE-2) raised to a beta-galactosidase-preproenkephalin A(69-207) fusion peptide recognize pro-enkephalin A (pro-enk-A) peptides of 33-5 kDa isolated from bovine adrenal chromaffin granules.
PE-1 Binding (recognize) of associated with enkephalin
4) Confidence 0.15 Published 1989 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2775454 Disease Relevance 0 Pain Relevance 0.10
With regard to serum TG and TG/HDL, a recognized marker of MetS, subjects in both arms experienced reductions at 8 weeks.
MetS Binding (recognized) of in arms associated with metabolic syndrome and disorder of lipid metabolism
5) Confidence 0.13 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.11 Pain Relevance 0
Peak I contained PE-1-and PE-2-immunoreactive peptides of 33, 29, 24 and 22 kDa; peak II contained a peptide of 22 kDa recognized by PE-2, and peptides of 24 and 22 kDa recognized by PE-1; peak III contained a PE-2-immunoreactive peptide of 15 kDa and PE-1-immunoreactive peptide of 18 kDa.
PE-1 Binding (recognized) of
6) Confidence 0.11 Published 1989 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2775454 Disease Relevance 0 Pain Relevance 0.07
The 15 kDa (PE-2-immunoreactive) band was recognized by the peptide F but not the MetEnk-RGL antibody, whereas the polyclonal antibodies did not recognize the 18 kDa (PE-1-immunoreactive) band.
PE-1-immunoreactive Neg (not) Binding (recognize) of in band
7) Confidence 0.10 Published 1989 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2775454 Disease Relevance 0 Pain Relevance 0.09

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