INT285418

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (IL6) aging (IL6)
extracellular region (IL6) nucleus (IRF6) DNA binding (IRF6)
Anatomy Link Frequency
corneal epithelial cell 2
IRF6 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 43 99.78 Very High Very High Very High
cytokine 87 96.40 Very High Very High Very High
Inflammation 83 94.04 High High
agonist 7 55.96 Quite High
Inflammatory response 15 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 106 94.04 High High
Herpes Simplex Virus 2 86.68 High High
Necrosis 3 79.72 Quite High
Cancer 3 79.36 Quite High
Hypersensitivity 5 77.36 Quite High
Pre-term Labor 4 57.68 Quite High
Bacterial Respiratory Disease 1 44.96 Quite Low
Infection 15 41.76 Quite Low
Pseudomonas Infection 2 23.52 Low Low
Premature Birth 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the studies showed that the presence of LPS stimulated the secretion of IL-6 and IL-8 in a human corneal epithelial cell line, which could be further inhibited by adding antibody against CD14, clearly suggested a functional TLR4 in these cells [16].
LPS Positive_regulation (stimulated) of Localization (secretion) of IL-6 in corneal epithelial cell
1) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.22 Pain Relevance 0.05
from human gestational membranes in Transwell cultures [23], and show for the first time that releases of IL-6, IL-8 and IL-10 are stimulated by LPS in a side-specific manner from human gestational membranes.
LPS Positive_regulation (stimulated) of Localization (releases) of IL-6
2) Confidence 0.04 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.22 Pain Relevance 0.24
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
LPS Positive_regulation (induced) of Localization (release) of IL-6 associated with dexamethasone
3) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.23 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox