INT285436

Context Info Confidence 0.24 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.07

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency cornea 2 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 9 72.16 Inflammation 2 71.76 Inflammatory response 11 5.00 tolerance 2 5.00 chemokine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 1 96.08 Herpes Simplex Virus 2 93.28 INFLAMMATION 13 71.76 Bacterial Respiratory Disease 1 63.68 Cadaver 4 5.00 Death 3 5.00 Pseudomonas Infection 2 5.00 Sprains And Strains 1 5.00 Congenital Anomalies 1 5.00 Vibrio Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In human cornea, multiple groups have reported the expression of TLR3 [14,15], TLR4 [16,17], and TLR5 [18] mRNA and proteins.

Negative_regulation (reported) of Transcription (expression) of TLR3 in cornea

1) Confidence 0.24 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.32 Pain Relevance 0.07

General Comments

This test has worked.