INT285439

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.06
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR5) plasma membrane (TLR5) intracellular (TLR5)
Anatomy Link Frequency
conjunctiva 1
cornea 1
TLR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 27 72.24 Quite High
cytokine 30 67.52 Quite High
Inflammation 23 67.12 Quite High
Bile 12 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 102 93.16 High High
Death 25 78.56 Quite High
Influenza Virus Infection 35 74.56 Quite High
Sprains And Strains 48 73.12 Quite High
INFLAMMATION 40 72.24 Quite High
Bordatella Infection 1 61.96 Quite High
Vibrio Infection 3 61.04 Quite High
Injury 6 50.48 Quite High
Fever 25 5.00 Very Low Very Low Very Low
Gastroenteritis 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRP rises when interleukin-6 is elevated which is most likely due to the stimulation of the TLR5 receptor by flagellin. [13] TIV alone does not induce this type of response.
Positive_regulation (stimulation) of TLR5 receptor
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3010987 Disease Relevance 0.33 Pain Relevance 0
Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.
Positive_regulation (results) of TLR5 in cornea
2) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
TLR5 activation induces NF-?
Positive_regulation (activation) of TLR5
3) Confidence 0.23 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.20 Pain Relevance 0.03
However, activation of TLR5 located on the apical surface of IECs by flagellin leads to an increase in the expression of antiapoptotic genes.
Positive_regulation (activation) of TLR5
4) Confidence 0.17 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.16 Pain Relevance 0.04
In our studies bacteria were washed before addition to the cells and were treated at a temperature unlikely to dissociate flagellin monomers [50], thereby minimising the amounts of flagellin monomers present to trigger TLR5.
Positive_regulation (trigger) of TLR5
5) Confidence 0.13 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.37 Pain Relevance 0.07
Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.
Positive_regulation (results) of TLR5 in conjunctiva
6) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox