INT28544

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 2008
Negated 2
Speculated 3
Reported most in Abstract
Documents 6
Total Number 10
Disease Relevance 1.04
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
striatum 3
spinal 2
dentate gyrus 2
adrenal gland 2
neuronal 1
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 15 100.00 Very High Very High Very High
dexamethasone 11 99.82 Very High Very High Very High
Hippocampus 12 99.64 Very High Very High Very High
Morphine 10 99.52 Very High Very High Very High
medulla 4 99.36 Very High Very High Very High
narcan 5 99.28 Very High Very High Very High
sodium channel 4 99.18 Very High Very High Very High
Enkephalin 18 98.96 Very High Very High Very High
Catecholamine 3 98.36 Very High Very High Very High
withdrawal 5 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arterial-venous Cerebral Malformations 1 100.00 Very High Very High Very High
Epilepsy 1 97.76 Very High Very High Very High
Pain 1 96.36 Very High Very High Very High
Morphine Dependence 3 96.12 Very High Very High Very High
Convulsion 6 80.80 Quite High
Absence Epilepsy 2 75.00 Quite High
Insulin Resistance 40 70.88 Quite High
Thyroid Disease 1 62.68 Quite High
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, dexamethasone did not affect the expression of proDYN mRNA level induced by forskolin.
Neg (not) Regulation (affect) of Gene_expression (expression) of proDYN mRNA associated with dexamethasone
1) Confidence 0.24 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.41
The effect of deep prepyriform cortex (DPC) kindling on the levels of prodynorphin mRNA (DYN mRNA) in rat hippocampus and striatum was examined under two different stimulation paradigms.
Spec (examined) Regulation (effect) of Gene_expression (levels) of DYN mRNA in striatum associated with hippocampus
2) Confidence 0.15 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.15 Pain Relevance 0.12
The effect of deep prepyriform cortex (DPC) kindling on the levels of prodynorphin mRNA (DYN mRNA) in rat hippocampus and striatum was examined under two different stimulation paradigms.
Spec (examined) Regulation (effect) of in hippocampus Gene_expression (levels) of DYN mRNA in striatum associated with hippocampus
3) Confidence 0.05 Published 1989 Journal Brain Res. Section Abstract Doc Link 2776033 Disease Relevance 0.15 Pain Relevance 0.12
This effect could be directly mediated though the thyroid hormone nuclear receptor or could be secondary to changes in glutamatergic transmission in the dentate gyrus, as suggested by the profound alteration of the KA-induced expression of DYN mRNA in the dentate gyrus of hypo-and hyperthyroid rats.
Regulation (alteration) of Gene_expression (expression) of DYN mRNA in dentate gyrus associated with dynorphin
4) Confidence 0.04 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583317 Disease Relevance 0.06 Pain Relevance 0.63
The differences in expression of TH mRNA and PPEnk mRNA in the adrenal medulla in situ, in explants in culture and in transplants in the spinal subarachnoid space, indicate that the mechanisms regulating the expression of neurohumoral factors depend upon environmental factors extrinsic to the medullary cells themselves.
Regulation (differences) of Gene_expression (expression) of PPEnk mRNA in spinal associated with medulla
5) Confidence 0.03 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0.10 Pain Relevance 0.51
By contrast, injection of saline or naloxone to morphine dependent rats did not affect the intensity of AVM mRNA expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of AVM mRNA associated with narcan, arterial-venous cerebral malformations and morphine
6) Confidence 0.03 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12431775 Disease Relevance 0.27 Pain Relevance 1.36
Due to the involvement of cortical neurons in spike-wave discharge (SWD) initiation, and the contribution of voltage-gated sodium channels (VGSCs) to neuronal firing, we examined alterations in the expression of VGSC mRNA and protein in cortical neurons in the WAG/Rij absence epileptic rat.
Spec (examined) Regulation (alterations) of in neurons Gene_expression (expression) of VGSC mRNA in neuronal associated with epilepsy and sodium channel
7) Confidence 0.02 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.17 Pain Relevance 0.38
The IC50_DR(N) represents the concentration of DR(N) at which the production rate of mRNA is reduced to 50% of its baseline level under the inhibition of DR(N).
Regulation (under) of Gene_expression (production) of mRNA
8) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.09
They can also accommodate convergence of cascades that commonly occur in the control of the expression of genes where binding sites for multiple nuclear factors participate in the regulation of the level of expression of a particular mRNA.
Regulation (regulation) of Gene_expression (expression) of mRNA
9) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.13 Pain Relevance 0.04
Similarly, the effect of lipopolysaccharides on preproenkephalin A mRNA expression in the adrenal gland was analyzed.
Regulation (effect) of Gene_expression (expression) of mRNA in adrenal gland
10) Confidence 0.01 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8521141 Disease Relevance 0 Pain Relevance 0.29

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