INT285448

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.58
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
Anatomy Link Frequency
corneal epithelium 2
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 11 92.92 High High
Inflammatory response 28 92.32 High High
cytokine 59 89.44 High High
agonist 22 79.24 Quite High
Inflammation 35 66.04 Quite High
tolerance 4 34.76 Quite Low
headache 2 24.12 Low Low
chemokine 22 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 4 99.98 Very High Very High Very High
Disease 39 97.28 Very High Very High Very High
Critical Illness 74 96.40 Very High Very High Very High
INFLAMMATION 64 92.32 High High
Hypersensitivity 2 90.36 High High
Infection 26 85.68 High High
Death 8 72.68 Quite High
Influenza Virus Infection 30 65.16 Quite High
Bacterial Respiratory Disease 2 57.96 Quite High
Dyspnea 2 26.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, it was recently found that herpes simplex virus induced TLR7 expression in human corneal cells [19].
Positive_regulation (induced) of Gene_expression (expression) of TLR7 associated with herpes simplex virus
1) Confidence 0.61 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.51 Pain Relevance 0.20
A recent study showed that herpes simplex virus, HSVI, induced the expression of TLR7 in corneal epithelium [19].
Positive_regulation (induced) of Gene_expression (expression) of TLR7 in corneal epithelium associated with herpes simplex virus
2) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.31 Pain Relevance 0.07
g/ml acting predominantly at TLR7) did not give any detectable release of IL-1?
Positive_regulation (at) of Gene_expression (acting) of TLR7
3) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.15
0.0009) and rise in TLR3, TLR4, TLR7 levels (p?
Positive_regulation (rise) of Gene_expression (levels) of TLR7
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.94 Pain Relevance 0.04
The expression of TLR3, TLR4, TLR7, TLR8 and TLR9 was significantly higher in mild cases than controls (p?
Positive_regulation (higher) of Gene_expression (expression) of TLR7
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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