INT28546

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Context Info
Confidence 0.54
First Reported 1974
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 16.35
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
blood 1
thyroid 1
pituitary 1
EPI 1
Kidney 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 6 99.84 Very High Very High Very High
Paracetamol 11 99.58 Very High Very High Very High
Pain 25 99.40 Very High Very High Very High
Mcgill questionnaire 1 99.00 Very High Very High Very High
methadone 9 98.76 Very High Very High Very High
anesthesia 4 98.74 Very High Very High Very High
Angina 8 96.28 Very High Very High Very High
fibrosis 1 89.76 High High
Analgesic 2 86.16 High High
antagonist 1 85.64 High High
Disease Link Frequency Relevance Heat
Hypertension 56 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 100.00 Very High Very High Very High
Cv Unclassified Under Development 7 100.00 Very High Very High Very High
Infection 5 100.00 Very High Very High Very High
Headache 7 99.84 Very High Very High Very High
Pain 20 99.40 Very High Very High Very High
Stress 91 99.32 Very High Very High Very High
Dizziness 6 99.04 Very High Very High Very High
Disorder Of Lipid Metabolism 75 98.62 Very High Very High Very High
Toxicity 6 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SHBG levels are easily affected by many conditions, so total testosterone measurements can therefore be misleading indicators of hypogonadism.
Regulation (affected) of SHBG associated with hypogonadotropic hypogonadism
1) Confidence 0.54 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.32 Pain Relevance 0
Changes in the second category which may occur affect the adrenal glands, hypothalamus, the thyroid (increased thyroid-binding globulin), and pancreas (alterations in glucose metabolism).
Regulation (affect) of thyroid-binding globulin in thyroid
2) Confidence 0.45 Published 1974 Journal Clin Obstet Gynecol Section Abstract Doc Link 4596680 Disease Relevance 1.19 Pain Relevance 0.19
In most randomised studies, combinations of verapamil SR 120 to 240 mg/day and trandolapril 0.5 to 8 mg/day were significantly more effective in lowering sitting DBP and SBP than the corresponding monotherapies administered at the same dosage.
Regulation (effective) of SBP
3) Confidence 0.44 Published 2002 Journal Drugs Section Abstract Doc Link 12421112 Disease Relevance 0.16 Pain Relevance 0.09
Valsartan/hydrochlorothiazide also provided effective 24-hour ambulatory SBP/DBP control.
Regulation (control) of SBP
4) Confidence 0.44 Published 2002 Journal Drugs Section Abstract Doc Link 12215069 Disease Relevance 0.64 Pain Relevance 0.10
Only HDL-cholesterol, triglycerides, apo B, fasting insulin, HOMA index,
   SHBG, CRP and adiponectin concentrations were significantly different in the bottom tertile
   (lean individuals) from those in the other tertiles. 
Regulation (different) of SHBG associated with disorder of lipid metabolism
5) Confidence 0.37 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.53 Pain Relevance 0
Peak exercise data revealed main effects of pain on SBP, RPP and HR, and main effects of ischaemia on SBP and RPP, controlling for age, sex, baseline level, medication status and cardiac history.
Regulation (effects) of SBP associated with pain and cv unclassified under development
6) Confidence 0.26 Published 2006 Journal J Hum Hypertens Section Abstract Doc Link 16710292 Disease Relevance 1.57 Pain Relevance 0.54
OBJECTIVE: To study the effect of Shexiang Baoxin pill (SBP) on the vascular endothelial function in patients with diabetes mellitus type 2 (DM2) complicated with angina pectoris.
Regulation (effect) of SBP associated with angina and diabetes mellitus
7) Confidence 0.26 Published 2004 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 15658648 Disease Relevance 0.34 Pain Relevance 0.17
PH+ men showed greater SBP and DBP responses to the cold pressor test.
Regulation (responses) of SBP
8) Confidence 0.26 Published 1996 Journal Psychophysiology Section Abstract Doc Link 8961787 Disease Relevance 1.03 Pain Relevance 0.78
Associated with target organ toxicity is selective arylation of proteins, with a 58-kDa acetaminophen binding protein (58-ABP) being the most prominent cytosolic target.
Regulation (target) of ABP associated with toxicity and paracetamol
9) Confidence 0.26 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8937897 Disease Relevance 0.74 Pain Relevance 0.82
During anesthesia and in the recovery room, there were more moderate and severe alterations of ABP and HR in the control group than in the treated grups, with the only statistically significant differences being those between group 1 and group 3.
Regulation (alterations) of ABP associated with anesthesia
10) Confidence 0.26 Published 1980 Journal Arch Surg Section Abstract Doc Link 7425833 Disease Relevance 0.16 Pain Relevance 0.18
Failure to consider genotype may mask significant associations with diet; likewise, the effects of genetic polymorphisms may be detectable only with specific dietary exposures (that is, the effect of dietary isoflavone intake on levels of sex-hormone binding globulin among women with the N-variant of the D356N gene) [96].
Regulation (effect) of sex-hormone binding globulin
11) Confidence 0.26 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 1.12 Pain Relevance 0
The more severe the "Kidney deficiency" was, the more significant the changes of sex hormone were.
Regulation (changes) of sex hormone in Kidney
12) Confidence 0.24 Published 1989 Journal Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 2776274 Disease Relevance 1.04 Pain Relevance 0.09
Other artefacts including slight movements of the hand holding the Doppler device during manual inflation and deflation, alterations in the position or angle of the device, and variations in the amount of pressure can affect the quality of the Doppler signal, and consequently the SBP measurement [13].
Regulation (affect) of SBP
13) Confidence 0.18 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2567287 Disease Relevance 0.55 Pain Relevance 0
The effects of illicit drug use and HIV infection on sex hormone levels in women.
Regulation (effects) of sex hormone associated with acquired immune deficiency syndrome or hiv infection and infection
14) Confidence 0.17 Published 2006 Journal Gynecol. Endocrinol. Section Title Doc Link 16785144 Disease Relevance 0.66 Pain Relevance 0.16
Drug use and HIV infection may affect sex hormone levels in women.
Spec (may) Regulation (affect) of sex hormone associated with acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.17 Published 2006 Journal Gynecol. Endocrinol. Section Abstract Doc Link 16785144 Disease Relevance 0.58 Pain Relevance 0.13
The effects of perindopril-based therapy were similar for both hypertensive (SBP ?
Regulation (effects) of SBP associated with hypertension
16) Confidence 0.13 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 1.11 Pain Relevance 0.04
The supplement had no statistically significant effect on blood EPI or NE concentration, or on HR, SBP, or DBP.
Neg (no) Regulation (effect) of SBP in EPI
17) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2912905 Disease Relevance 0.22 Pain Relevance 0
No differences were observed between the novelty stress and stress periods on day 1 and between the control 1 and 2 on day 2 for SBP, DBP, MAP and HR.
Regulation (control) of SBP associated with stress
18) Confidence 0.09 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.60 Pain Relevance 0
In addition to the SBP responses, the hemodynamic variables resting HR and DBP were not affected by either of the coffees, which are in agreement with previous research [16,24].
Neg (not) Regulation (affected) of SBP
19) Confidence 0.08 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2098780 Disease Relevance 0.14 Pain Relevance 0
In Raff and colleaguesÂ’ (2006) investigation, a diet rich in CLAs didnÂ’t alter SBP, DBP and pulse pressure, but this may be due to the short time for the study (five weeks).
Regulation (alter) of SBP
20) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663461 Disease Relevance 0.57 Pain Relevance 0

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