INT285469

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zeb1) nucleus (Zeb1) intracellular (Zeb1)
DNA binding (Zeb1) transcription factor binding (Zeb1) cytoplasm (Zeb1)
Anatomy Link Frequency
T cells 2
Zeb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 48 96.88 Very High Very High Very High
chemokine 17 96.88 Very High Very High Very High
cytokine 53 81.24 Quite High
gABA 1 53.96 Quite High
Inflammatory mediators 4 42.52 Quite Low
Inflammation 44 35.72 Quite Low
rheumatoid arthritis 88 5.00 Very Low Very Low Very Low
psoriasis 44 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 57 96.88 Very High Very High Very High
Apoptosis 11 83.24 Quite High
Adhesions 2 63.76 Quite High
Death 10 56.96 Quite High
Lymphatic System Cancer 2 53.04 Quite High
Autoimmune Disease 33 50.00 Quite Low
INFLAMMATION 45 42.12 Quite Low
Necrosis 5 32.08 Quite Low
Cancer 5 31.72 Quite Low
Rheumatoid Arthritis 89 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The top 30 differentially expressed genes in the T cell population included upregulation of transcription factor 8 (TCF8), a known transcription repressor for IL-2 in T cells, and downregulation of chemokine receptor CCR5, and RGS14, a known downregulator of signaling through G protein-coupled receptors in MS.
Positive_regulation (upregulation) of Transcription (transcription) of TCF8 in T cells associated with chemokine and multiple sclerosis
1) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.61 Pain Relevance 0.33

General Comments

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