INT285470

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.18
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 146 100.00 Very High Very High Very High
Inflammatory response 8 99.76 Very High Very High Very High
Inflammation 122 99.26 Very High Very High Very High
rheumatoid arthritis 88 99.06 Very High Very High Very High
psoriasis 99 93.44 High High
chemokine 25 78.48 Quite High
ischemia 1 65.44 Quite High
depression 2 46.84 Quite Low
antagonist 6 15.92 Low Low
Etanercept 25 5.20 Low Low
Disease Link Frequency Relevance Heat
Burns 63 99.98 Very High Very High Very High
INFLAMMATION 129 99.58 Very High Very High Very High
Asthma 104 99.46 Very High Very High Very High
Rheumatoid Arthritis 89 99.06 Very High Very High Very High
Disease 114 98.44 Very High Very High Very High
Injury 23 94.08 High High
Psoriasis 117 93.44 High High
Occupational Lung Diseases 4 88.36 High High
Skin Diseases 5 82.08 Quite High
Infection 29 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In that regard, results from the present study demonstrate that the early cardiac inflammatory response after burn involves IL-17 and other Th-17 cytokines (IL-6, IL-22).
Regulation (involves) of IL-22 associated with inflammatory response, burns and cytokine
1) Confidence 0.11 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.45 Pain Relevance 0.40
These pro-inflammatory Th22 responses were synergistically dependent on IL-22 and TNF-?.
Regulation (dependent) of IL-22 associated with inflammation
2) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.13 Pain Relevance 0.38
and IL-6 have meanwhile been implicated in at least several aspects of asthma pathogenesis [93–95], the effects of other TH17 cell derived factors such as IL-17F, IL-22, and IL-26 have only been investigated fragmentarily.
Spec (investigated) Regulation (effects) of IL-22 associated with asthma
3) Confidence 0.08 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.58 Pain Relevance 0.16
In own experiments using oligonucleotide microarray technology to monitor disease course of rheumatoid arthritis patients by analysis of PBMC gene expression, values of IL-23, IL-17, and IL-22 were indeed generally below or only slightly above detection limits (unpublished observation).
Regulation (values) of IL-22 associated with rheumatoid arthritis and disease
4) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.01 Pain Relevance 0.28

General Comments

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