INT285471

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 88 96.20 Very High Very High Very High
Inflammation 70 85.08 High High
anakinra 4 63.28 Quite High
Arthritis 26 61.48 Quite High
Etanercept 8 55.52 Quite High
cytokine 57 50.00 Quite Low
antagonist 4 32.68 Quite Low
psoriasis 44 15.76 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 89 96.20 Very High Very High Very High
Sepsis 18 95.72 Very High Very High Very High
Autoimmune Disease 33 95.56 Very High Very High Very High
Bacterial Pneumonia 1 86.72 High High
Disease 69 85.44 High High
Pneumonia 30 85.12 High High
INFLAMMATION 80 85.08 High High
Congenital Anomalies 5 72.56 Quite High
Nicotine Addiction 3 67.92 Quite High
Juvenile Chronic Polyarthritis 1 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, we repeated our analyses of IL-6 and D-dimer in subjects with similar etiology based on procalcitonin (PCT) stratification, since patients with high PCT (?
Spec (analyses) Negative_regulation (repeated) of IL-6 Spec (analyses) Binding (analyses) of
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.41 Pain Relevance 0
A humanized version of an anti-IL-6 receptor monoclonal antibody, termed tocilizumab (TCZ), was developed to block IL-6 receptor binding and has been tested in a series of clinical phase III trials as a potential new treatment for RA [135–138].
Negative_regulation (block) of IL-6 Binding (binding) of associated with rheumatoid arthritis
2) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.92 Pain Relevance 0.41

General Comments

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