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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zeb1) nucleus (Zeb1) intracellular (Zeb1)
DNA binding (Zeb1) transcription factor binding (Zeb1) cytoplasm (Zeb1)
Anatomy Link Frequency
T cells 1
Zeb1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 2 99.92 Very High Very High Very High
dopamine receptor 1 99.48 Very High Very High Very High
addiction 1 99.48 Very High Very High Very High
withdrawal 4 99.00 Very High Very High Very High
Multiple sclerosis 48 96.88 Very High Very High Very High
chemokine 17 96.88 Very High Very High Very High
Serotonin 3 92.76 High High
Dopamine 1 91.88 High High
Bioavailability 1 88.80 High High
cytokine 54 81.24 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 2 99.18 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 4 98.76 Very High Very High Very High
Multiple Sclerosis 57 96.88 Very High Very High Very High
Apoptosis 15 83.24 Quite High
Adhesions 2 63.76 Quite High
Death 13 56.96 Quite High
Lymphatic System Cancer 2 53.04 Quite High
Arrhythmia Under Development 4 50.28 Quite High
Disease 164 50.00 Quite Low
Autoimmune Disease 33 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The top 30 differentially expressed genes in the T cell population included upregulation of transcription factor 8 (TCF8), a known transcription repressor for IL-2 in T cells, and downregulation of chemokine receptor CCR5, and RGS14, a known downregulator of signaling through G protein-coupled receptors in MS.
Positive_regulation (upregulation) of TCF8 in T cells associated with chemokine and multiple sclerosis
1) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.61 Pain Relevance 0.33
Hence ramelteon has advantages over other hypnotic drugs in not causing rebound insomnia, withdrawal symptoms, or dependence which is common with the activation of BZP, opiate, or dopamine receptors.
Positive_regulation (activation) of BZP associated with addiction, sleep initiation and maintenance disorders, dopamine receptor, opiate and withdrawal
2) Confidence 0.14 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.25 Pain Relevance 0.54

General Comments

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