INT285484

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col10a1) proteinaceous extracellular matrix (Col10a1)
Anatomy Link Frequency
skin 1
articular cartilage 1
Col10a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 58 69.28 Quite High
Osteoarthritis 96 54.00 Quite High
rheumatoid arthritis 88 5.00 Very Low Very Low Very Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Inflammation 45 5.00 Very Low Very Low Very Low
psoriasis 44 5.00 Very Low Very Low Very Low
Arthritis 27 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Diseases 2 92.96 High High
Systemic Sclerosis 34 88.56 High High
Limited Scleroderma 1 87.28 High High
Diffuse Scleroderma 1 85.16 High High
Hypersensitivity 1 74.68 Quite High
Cancer 6 73.52 Quite High
Necrosis 6 73.04 Quite High
Hypertrophy 5 66.32 Quite High
Targeted Disruption 5 64.00 Quite High
Osteoarthritis 101 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in gene expression in diseased versus normal skin included a series of collagen genes such as COL5A2, COL8A1, COL10A1, COL12A1.
Negative_regulation (series) of COL10A1 in skin
1) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.08 Pain Relevance 0.10
Mutant mice deficient for functional Smad3 show abnormally increased numbers of type X collagen-expressing chondrocytes in articular cartilage.
Negative_regulation (numbers) of type X collagen in articular cartilage
2) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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