INT285501

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.09
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

homeostatic process (Smad1) nucleus (Smad1) intracellular (Smad1)
cytoplasm (Smad1)
Anatomy Link Frequency
chondrocytes 1
articular 1
Smad1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 73 97.92 Very High Very High Very High
Osteoarthritis 369 88.00 High High
fibrosis 27 58.32 Quite High
rheumatoid arthritis 88 5.00 Very Low Very Low Very Low
Inflammation 52 5.00 Very Low Very Low Very Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
psoriasis 44 5.00 Very Low Very Low Very Low
Arthritis 30 5.00 Very Low Very Low Very Low
chemokine 17 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 34 95.52 Very High Very High Very High
Hypertrophy 20 95.12 Very High Very High Very High
Necrosis 9 93.08 High High
Targeted Disruption 8 92.80 High High
Cancer 9 92.72 High High
Aging 52 89.92 High High
Osteoarthritis 389 88.00 High High
Skin Diseases 2 83.28 Quite High
Limited Scleroderma 1 64.32 Quite High
Diffuse Scleroderma 1 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylated (pSMAD1, pSMAD2) forms of the protein were examined by western blotting, with total SMAD1 and ?
Spec (examined) Gene_expression (examined) of SMAD1
1) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.16 Pain Relevance 0.03
BMP-2 increased pSMAD1 levels, and also reduced pSMAD2 levels.
Gene_expression (levels) of pSMAD1
2) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.11 Pain Relevance 0.03
The phosphorylated (pSMAD1, pSMAD2) forms of the protein were examined by western blotting, with total SMAD1 and ?
Spec (examined) Gene_expression (examined) of pSMAD1
3) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.17 Pain Relevance 0
The phosphorylated (pSMAD1, pSMAD2) forms of the protein were examined by western blotting, with total SMAD1 and ?
Gene_expression (forms) of pSMAD1
4) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.17 Pain Relevance 0
In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.
Gene_expression (expression) of Smad1 in articular
5) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.43 Pain Relevance 0.03
The ALK1 (Smad1/5/8) and ALK5 (Smad3) signaling balance in chondrocytes apparently determines MMP-13 expression.
Gene_expression (/) of Smad1 in chondrocytes
6) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06
The Smad2/3 and Smad1/5/8 balance controls the Runx2 function and terminal differentiation.


Gene_expression (/) of Smad1
7) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.60 Pain Relevance 0.16
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Gene_expression (expression) of Smad1
8) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.25 Pain Relevance 0.06
The low expressed genes included SMAD1, IL-15, CXCL5.
Gene_expression (expressed) of SMAD1
9) Confidence 0.21 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.94 Pain Relevance 0.05

General Comments

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