INT285560

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.45
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a, Il17a) extracellular region (Il23a, Il17a)
Anatomy Link Frequency
Th17 cells 1
Il23a (Mus musculus)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 44 98.44 Very High Very High Very High
rheumatoid arthritis 88 96.16 Very High Very High Very High
Arthritis 26 94.08 High High
cytokine 53 50.00 Quite Low
Multiple sclerosis 48 43.04 Quite Low
Crohn's disease 4 27.52 Quite Low
psoriasis 44 26.36 Quite Low
Inflammatory mediators 4 12.96 Low Low
chemokine 17 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 69 100.00 Very High Very High Very High
INFLAMMATION 45 98.44 Very High Very High Very High
Rheumatoid Arthritis 89 96.16 Very High Very High Very High
Arthritis 16 94.08 High High
Targeted Disruption 4 92.28 High High
Autoimmune Disease 33 60.56 Quite High
Diabetes Mellitus 8 43.88 Quite Low
Multiple Sclerosis 57 43.04 Quite Low
Systemic Lupus Erythematosus 65 42.88 Quite Low
Psoriasis 49 26.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these experiments, p19-deficient mice were resistant to the disease and unable to generate IL-17-producing CD4+ T cells (Th17 cells), while deletion of the IL12/p35 chain even had disease promoting effects, arguing for a disease-protective role of IL-12 in this setting.
p19 Neg (unable) Positive_regulation (generate) of IL-17 in Th17 cells associated with disease
1) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.45 Pain Relevance 0.39

General Comments

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