INT285561

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.45
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a, Il22) extracellular region (Il23a, Il22)
Anatomy Link Frequency
ear 2
T cells 2
Il23a (Mus musculus)
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 59 99.20 Very High Very High Very High
rheumatoid arthritis 142 92.40 High High
cytokine 86 91.84 High High
Arthritis 112 89.44 High High
psoriasis 44 84.40 Quite High
Inflammatory mediators 4 59.28 Quite High
Multiple sclerosis 48 7.76 Low Low
chemokine 18 5.00 Very Low Very Low Very Low
Adalimumab 9 5.00 Very Low Very Low Very Low
Crohn's disease 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 64 99.58 Very High Very High Very High
INFLAMMATION 57 99.20 Very High Very High Very High
Rheumatoid Arthritis 143 92.40 High High
Pressure And Volume Under Development 2 90.56 High High
Arthritis 85 89.44 High High
Targeted Disruption 5 87.88 High High
Psoriasis 49 84.40 Quite High
Acanthosis 4 83.20 Quite High
Systemic Lupus Erythematosus 77 64.76 Quite High
Disease 99 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with other inflammatory models such as EAE [43], we found that IL-23 is essential for IL-22 production in polarized CD4+ T cells from naïve and type II collagen-immunized DBA/1 mice [66].
IL-23 Positive_regulation (essential) of Gene_expression (production) of IL-22 in T cells associated with multiple sclerosis and inflammation
1) Confidence 0.06 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.17 Pain Relevance 0.49
When injected into mouse ear, IL-23 induced the production of both IL-22 and IL-17, as shown by reverse transcriptase polymerase chain reaction (RT-PCR) analysis.
IL-23 Positive_regulation (induced) of Gene_expression (production) of IL-22 in ear
2) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.28 Pain Relevance 0.44

General Comments

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