INT285569

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.83
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il6) extracellular region (TNF, Il6) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 176 100.00 Very High Very High Very High
cytokine 106 100.00 Very High Very High Very High
Inflammation 88 96.56 Very High Very High Very High
Pain 2 96.00 Very High Very High Very High
Infliximab 10 73.28 Quite High
methotrexate 10 64.96 Quite High
psoriasis 88 52.56 Quite High
cINOD 2 49.20 Quite Low
Multiple sclerosis 96 49.12 Quite Low
Arthritis 52 38.56 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 178 100.00 Very High Very High Very High
Pressure And Volume Under Development 4 96.96 Very High Very High Very High
INFLAMMATION 90 96.56 Very High Very High Very High
Arthralgia 2 96.00 Very High Very High Very High
Systemic Lupus Erythematosus 130 88.12 High High
Autoimmune Disease 66 87.64 High High
Disease 138 86.32 High High
Psoriasis 98 52.56 Quite High
Inflammatory Bowel Disease 4 51.68 Quite High
Multiple Sclerosis 114 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Later on, a major breakthrough was the observation that expression of proinflammatory cytokines IL-1, IL-6, IL-8, and GM-CSF, produced by synoviocytes isolated from RA patients, could be blocked by addition of a TNF neutralizing antibody [127].
TNF Negative_regulation (blocked) of Gene_expression (expression) of IL-6 associated with rheumatoid arthritis and cytokine
1) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.42 Pain Relevance 0.73
Later on, a major breakthrough was the observation that expression of proinflammatory cytokines IL-1, IL-6, IL-8, and GM-CSF, produced by synoviocytes isolated from RA patients, could be blocked by addition of a TNF neutralizing antibody [127].
TNF Negative_regulation (blocked) of Gene_expression (produced) of IL-6 associated with rheumatoid arthritis and cytokine
2) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.41 Pain Relevance 0.73

General Comments

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