INT285598

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Maoa, Aldh3a1) cytosol (Aldh3a1) mitochondrion (Maoa)
aging (Aldh3a1) endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Anatomy Link Frequency
brain 1
Maoa (Rattus norvegicus)
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 99.54 Very High Very High Very High
monoamine 1 65.76 Quite High
Neurotransmitter 2 51.64 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
ketamine 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 50 90.52 High High
Disease 31 43.64 Quite Low
Apoptosis 12 17.00 Low Low
Inflammatory Breast Neoplasms 34 5.00 Very Low Very Low Very Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Premature Birth 19 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low
Sepsis 17 5.00 Very Low Very Low Very Low
Cancer 16 5.00 Very Low Very Low Very Low
Breast Cancer 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using models for DA metabolism such as rat brain mitochondria, rat striatal synaptosomes and PC6-3 cells, both 4HNE and MDA were found to disrupt DA catabolism via potent inhibition of ALDH but not MAO at physiologic concentrations, yielding a several-fold increase in the level of cellular DOPAL.
MAO Negative_regulation (inhibition) of ALDH in brain associated with dopamine
1) Confidence 0.01 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

This test has worked.

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