INT28561

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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.83
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
eye 2
erythrocytes 2
anterior 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 51 99.80 Very High Very High Very High
Inflammation 108 97.20 Very High Very High Very High
Inflammatory response 10 94.16 High High
noradrenaline 1 91.28 High High
Osteoarthritis 1 90.40 High High
Arthritis 2 66.32 Quite High
cINOD 8 62.96 Quite High
Glutamate 1 32.28 Quite Low
metalloproteinase 3 32.04 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 102 99.52 Very High Very High Very High
Neurodegenerative Disease 25 97.60 Very High Very High Very High
INFLAMMATION 121 97.20 Very High Very High Very High
Osteoarthritis 1 90.40 High High
Toxicity 42 87.92 High High
Skin Cancer 7 87.52 High High
Colitis 1 87.24 High High
Stress 46 87.12 High High
Injury 9 81.60 Quite High
Death 20 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOD1 activity of blank HSA NP-treated cells was also evaluated as a control to study the effect of the vector alone on SOD1 expression.
Regulation (effect) of Gene_expression (expression) of SOD1
1) Confidence 0.61 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
The instability values for SOD1 variants were obtained from the equation normalized instability = 1 – average of normalized ??
Regulation (values) of Gene_expression (variants) of SOD1
2) Confidence 0.45 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0
These results indicate that changes in the SOD1 variants' properties, specifically increases in hydrophobicity and propensity to lose ?
Regulation (changes) of Gene_expression (variants) of SOD1
3) Confidence 0.45 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0 Pain Relevance 0
The aim of this study is to compare the in vivo effects of celecoxib, meloxicam, and ibuprofen on the activities of catalase (CAT), glutathione peroxidase (GSHPx), superoxide dismutase (SOD) as well as malondialdehyde (MDA), and antioxidant potential levels (AOP) in human erythrocytes.
Regulation (effects) of Gene_expression (activities) of SOD in erythrocytes
4) Confidence 0.39 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.18 Pain Relevance 0.16
Effects of a newly introduced polyoxyethylene-modified superoxide dismutase (SOD-POE) with prolonged plasma half life (10 h) on reperfusion induced arrhythmias were examined using a 15 min left anterior descending coronary artery (LAD) occlusion followed by reperfusion in the isolated perfused rat and guinea-pig hearts.
Spec (examined) Regulation (Effects) of Gene_expression (introduced) of SOD in anterior
5) Confidence 0.16 Published 1989 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 2778803 Disease Relevance 0 Pain Relevance 0
We found that over-expression of either SOD1 or SOD2 had no obvious effect on the eye in control flies, but dramatically enhanced the neurodegenerative phenotype seen in Q48 flies (Fig. 7C).


Neg (no) Regulation (effect) of Gene_expression (expression) of SOD1 in eye associated with neurodegenerative disease
6) Confidence 0.15 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.26 Pain Relevance 0
Melatonin, possesses genomic actions and regulates the expression of several genes including those for SOD and GSH-Px.
Regulation (regulates) of Gene_expression (expression) of SOD
7) Confidence 0.07 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.68 Pain Relevance 0.03
Indeed, the expression levels of heme oxygenase-1 (HO-1, data not shown) were also increased in the same set of samples for SOD detection.
Regulation (samples) of Gene_expression (detection) of SOD
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.33 Pain Relevance 0.09
whether agonists of PPARs act as SOD mimetics, or via other
Spec (whether) Regulation (act) of Gene_expression (mimetics) of SOD associated with agonist
9) Confidence 0.04 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.68 Pain Relevance 0.36
Thus, the change in the redox state (SOD and others) produced by the FRD will surely affect their concentrations.
Regulation (change) of Gene_expression (produced) of SOD
10) Confidence 0.03 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2974659 Disease Relevance 0.69 Pain Relevance 0.08
Actually, after a low-dose ciprofibrate-mediated peroxisome proliferation, SOD expression is modulated with a similar pattern to that observed in our model (18).
Regulation (modulated) of Gene_expression (expression) of SOD
11) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0 Pain Relevance 0

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